目的探讨高压氧治疗糖尿病足溃疡的疗效;临床研究

S. Babaniamansour, Nooshin Najari, Ehsan Aliniagerdroudbari, Amirmohammad Babaniamansour, Saeed Pezeshki
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引用次数: 0

摘要

引言:糖尿病足溃疡是糖尿病最常见的并发症之一。除了常规治疗外,高压氧治疗(HBOT)是DFU的一种辅助治疗方法。本研究旨在调查HBOT的疗效和可能的危险因素。方法:本研究于2016年9月至2017年9月在伊朗伊斯法罕和德黑兰的Bahar和Khatam两家高压诊所进行。符合条件的参与者每天(每周五天)在2至2.5个绝对大气压下接受100%氧气治疗90至120分钟。数据采用SPSS 24.0版软件进行分析。结果:58名入选患者的恢复率为69%,与良好的血糖控制状态、HBOT前(p<0.01)和期间(p<0.01)以及低度溃疡(p=0.04)有显著的直接关系。治愈患者的平均HBOT疗程数(21.5±17.1)显著高于未治愈患者的(11.3±7.9)(p=0.02)。然而,结论:HBOT治疗DFU疗效好,恢复率高。鉴于良好的血糖控制状态可以降低溃疡的发生率,这项研究表明,它提高了HBOT下DFU的恢复率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Hyperbaric Oxygen Therapy on Diabetic Foot Ulcer; a Clinical Study
Introduction:One of the most common diabetes complications is diabetic foot ulcer (DFU). Besides conventional treatments, hyperbaric oxygen therapy (HBOT) is known as an adjunctive therapy for DFU. This study aimed to investigate the efficacy of HBOT and possible risk factors. Methods:This study was conducted in two hyperbaric clinics of Bahar and Khatam, respectively in Isfahan and Tehran, Iran, between September 2016 and September 2017. Eligible participants underwent 100% oxygen at 2 to 2.5 atmosphere absolute for 90 to 120 minutes daily (five days per week). Data were analyzed with SPSS version 24.0. Results: The recovery rate was 69% in 58 enrolled patients and had a significant direct association with good glycemic control status, before (p <0.01) and during HBOT (P < 0.01), and low-grade ulcers (P= 0.04). The mean number of HBOT sessions of the cured patients (21.5±17.1) was significantly higher than that of the not cured patients (11.3 ± 7.9) (P= 0.02). However, the recovery rate had no significant association with the type of ulcer (P= 0.1). Conclusion: HBOT had good efficacy and a high recovery rate in DFU treatment. Given the fact that good glycemic control status reduces the incidence of ulcers, this study showed that it increased the DFU recovery rate under HBOT.
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