干饲料中添加苯甲酸钠/抗坏血酸组合对小鼠神经行为、氧化应激和炎症标志物的分级影响

Q2 Pharmacology, Toxicology and Pharmaceutics
O. Onaolapo, A. Olofinnade, A. Onaolapo
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引用次数: 0

摘要

在各种科学研究中,对苯甲酸钠/抗坏血酸组合的安全性提出了一些担忧。然而,关于它对大脑影响的科学文献却很少。本研究研究了添加苯甲酸钠/抗坏血酸的干饲料对小鼠神经行为、氧化应激和炎性细胞因子的影响。成年雄性小鼠分为10组,每组10只。一组喂食标准日粮,三组喂食含有125 mg/kg苯甲酸钠(NaB)和100、200或300 mg/kg抗坏血酸(AA)的日粮,另外三组分别喂食250 mg/kg NaB和100、300或300 mg/kg AA,最后三组分别喂500 mg/kg NaB,100、200和300 mg/kg AA。对行为测试进行评估,随后处死动物,并对其大脑进行匀浆以评估生化参数。结果显示,体重、自我打扮、总抗氧化能力、炎症细胞因子、与食物摄入的混合反应、运动活动、Y迷宫空间工作记忆和焦虑相关行为降低,养育和桡臂迷宫空间工作记忆力增加。添加NaB/AA的干饲料改变了小鼠的行为、氧化应激和炎症标志物。研究发现,根据食物中摄入的浓度,可能会产生有益和有害的影响。然而,还需要进一步的调查来确定其对人类的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Graded Effects of Dry-Feed Added Sodium Benzoate/Ascorbic Acid Combination on Neurobehaviour, Oxidative Stress, and Markers of Inflammation in Mice
Several concerns regarding the safety of sodium benzoate/ascorbic acid combination have been highlighted in various scientific investigations. However, there is a dearth of scientific literature on its effect on the brain. This study investigated the effects of dry-feed added sodium benzoate/ascorbic acid combination on neurobehaviour, oxidative stress, and inflammatory cytokines in mice Adult male mice were assigned into ten groups of 10 mice each. One group was fed a standard diet, three groups were fed a diet containing sodium benzoate (NaB) at 125 mg/kg with ascorbic acid (AA) at 100, 200, or 300 mg/kg of feed, another three groups were fed NaB at 250 mg/kg with AA at 100, 200, or 300 mg/kg of feed, respectively, and the last three groups were fed NaB at 500 mg/kg with AA at 100, 200 or 300 mg/kg, respectively. Behavioural tests were assessed, following which animals were sacrificed, and their brains were homogenised for the assessment of biochemical parameters. The result showed a decrease in body weight, self-grooming, total antioxidant capacity, inflammatory cytokines, mixed response with food intake, locomotor activity, Y maze spatial working memory, and anxiety-related behaviours and an increase in rearing and radial arm maze spatial working memory. Dry-feed added NaB/AA altered behavioural, oxidative stress, and inflammatory markers in mice. It was found that both beneficial and deleterious effects might be possible, depending on the concentrations ingested in food. However, further investigations are required to ascertain its effects on humans.
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来源期刊
Current Bioactive Compounds
Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.90
自引率
0.00%
发文量
112
期刊介绍: The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.
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