慢性丙型肝炎患者血清可溶性程序性死亡-1的变化及意义

Q4 Immunology and Microbiology

中华微生物学和免疫学杂志 Pub Date : 2019-12-31 DOI:10.3760/CMA.J.ISSN.0254-5101.2019.12.005

Xiaohui Huang, Liang Zhou, L. Gu, Xiaoyan Li, Yuehua Huang

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引用次数: 0

摘要

目的分析慢性丙型肝炎(CHC)患者血清可溶性程序性死亡-1 (sPD-1)的变化及其意义，探讨其在CHC进展中的作用。方法采用酶联免疫吸附试验(ELISA)检测CHC患者和健康对照组血清sPD-1水平，并进行比较。分析血清sPD-1与外周血丙型肝炎病毒(HCV) RNA、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)及肝纤维化(APRI指标)的相关性。结果CHC组血清sPD-1水平显著高于HC组(P<0.05)，且与外周血HCV RNA、ALT、AST呈正相关(P<0.05)。此外，APRI患者血清sPD-1水平大于1.2(严重肝纤维化)高于无肝纤维化或轻度肝纤维化患者(P<0.05)。结论sPD-1可能参与CHC的进展。检测CHC患者血清sPD-1有助于预测疾病进展，有助于做出正确的诊断和适当的临床治疗决策。关键词:可溶性程序性死亡1;慢性丙型肝炎;肝纤维化

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Changes and significance of serum soluble programmed death-1 in patients with chronic hepatitis C

Objective To analyze the changes and significance of serum soluble programmed death-1 (sPD-1) in patients with chronic hepatitis C (CHC) and study its role in the progression of CHC. Methods Serum levels of sPD-1 in CHC patients and healthy controls (HC) were measured using ELISA and compared. Correlations of serum sPD-1 with peripheral hepatitis C virus (HCV) RNA, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and liver fibrosis (indicated by APRI) were analyzed. Results The serum sPD-1 level in the CHC group was significantly higher than that in the HC group (P<0.05), and positively correlated with peripheral HCV RNA, ALT and AST (P<0.05). In addition, the serum sPD-1 levels in patients with APRI greater than 1.2 (indicating severe liver fibrosis) were higher than those in patients without or with mild liver fibrosis (P<0.05). Conclusions sPD-1 might be involve in the progression of CHC. Measuring serum sPD-1 in CHC patients would assist the prediction of disease progression and help to make the correct diagnosis and appropriate clinical therapy decision. Key words: Soluble programmed death-1; Chronic hepatitis C; Liver fibrosis

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来源期刊

中华微生物学和免疫学杂志 Immunology and Microbiology-Virology

CiteScore

0.50

自引率

0.00%

发文量

6906

期刊介绍： Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.