SARS- CoV-2蛋白及其功能

Q3 Pharmacology, Toxicology and Pharmaceutics

Vojenske Zdravotnicke Listy Pub Date : 2021-04-30 DOI:10.31482/MMSL.2021.018

Zohreh Taheri Kangarshahi, Shermin Lak, Mona Ghadam, N. Motamed, Sorosh Sardari, Samin Rahimi

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引用次数: 3

摘要

冠状病毒2型(SARS-CoV-2)导致2019年冠状病毒病，被认为是2020年的致命流行病。SARS-CoV-2是一种包膜、无节段、阳性RNA病毒，属于乙型冠状病毒家族。该病毒基因组约30 kb，编码16种非结构蛋白(Nsp1-16)， 4种结构蛋白(N、M、E、S)和9种辅助蛋白，参与病毒的生存和发病。为了生产针对SARS-CoV-2的药物和疫苗，必须充分了解该病毒的基因组结构及其蛋白质的功能。本综述收集并调查了迄今为止已报道的SARS-CoV-2蛋白的功能特性。©2021，国防大学，军事健康科学学院。版权所有。

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THE PROTEINS OF SARS- CoV-2 AND THEIR FUNCTIONS

Coronavirus 2 (SARS-CoV-2) leads to Coronavirus disease 2019, is recognized as a lethal epidemic in 2020. SARS-CoV-2 is an enveloped, non-segmented, positive sense RNA virus that belongs to the beta-corona family of viruses. The genome of this virus is about 30 kb representing 16 non-structural proteins (Nsp1-16), four structural proteins (N, M, E, S) and nine accessory proteins are encoded by its genome, which are involved in survival and pathogenesis the viruses. In order to produce medicines and vaccines for SARS-CoV-2, it is essential to fully understand the genomic structure of the virus and function of its proteins. This review collects and investigates the functional properties of SARS-CoV-2 proteins that have been reported to date. © 2021, University of Defence, Faculty of Military Health Sciences. All rights reserved.

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来源期刊

Vojenske Zdravotnicke Listy Health Professions-Emergency Medical Services

CiteScore

1.00

自引率

0.00%

发文量