Connor Quigley, Rokeya Sarah, Warren Hurd, Scott Clark, M. Habib
{"title":"生物3D打印过程中多水凝胶挤出内部喷嘴系统的设计与制造","authors":"Connor Quigley, Rokeya Sarah, Warren Hurd, Scott Clark, M. Habib","doi":"10.1115/1.4063357","DOIUrl":null,"url":null,"abstract":"\n The field of 3D bio-printing is rapidly expanding as researchers strive to create functional tissues for medical and pharmaceutical purposes. The ability to print multiple materials, each containing various living cells, brings us closer to achieving tissue regeneration. In a previous study, we designed a Y-shaped nozzle connector system that allowed for continuous deposition of multiple materials. This system was made of plastic and had a fixed switching angle, rendering it suitable for a single use. In this paper, we present the updated version of our nozzle system, which includes a range of angles (30°, 45°, 60°, and 90° degrees) between the two materials. We used stainless steel as the fabrication material and recorded the overall material switching time, comparing the effects of the various angles. Our previously developed hybrid hydrogel, which comprised 4% Alginate and 4% Carboxymethyl Cellulose (CMC), was used as a test material to flow through the nozzle system. The in-house fabricated nozzle connectors are reusable, sterile, and easy to clean, ensuring a smooth material transition and flow.","PeriodicalId":16299,"journal":{"name":"Journal of Manufacturing Science and Engineering-transactions of The Asme","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Design and Fabrication of In-house Nozzle System to Extrude Multi-Hydrogels for 3D Bioprinting Process\",\"authors\":\"Connor Quigley, Rokeya Sarah, Warren Hurd, Scott Clark, M. Habib\",\"doi\":\"10.1115/1.4063357\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n The field of 3D bio-printing is rapidly expanding as researchers strive to create functional tissues for medical and pharmaceutical purposes. The ability to print multiple materials, each containing various living cells, brings us closer to achieving tissue regeneration. In a previous study, we designed a Y-shaped nozzle connector system that allowed for continuous deposition of multiple materials. This system was made of plastic and had a fixed switching angle, rendering it suitable for a single use. In this paper, we present the updated version of our nozzle system, which includes a range of angles (30°, 45°, 60°, and 90° degrees) between the two materials. We used stainless steel as the fabrication material and recorded the overall material switching time, comparing the effects of the various angles. Our previously developed hybrid hydrogel, which comprised 4% Alginate and 4% Carboxymethyl Cellulose (CMC), was used as a test material to flow through the nozzle system. The in-house fabricated nozzle connectors are reusable, sterile, and easy to clean, ensuring a smooth material transition and flow.\",\"PeriodicalId\":16299,\"journal\":{\"name\":\"Journal of Manufacturing Science and Engineering-transactions of The Asme\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2023-09-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Manufacturing Science and Engineering-transactions of The Asme\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1115/1.4063357\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENGINEERING, MANUFACTURING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Manufacturing Science and Engineering-transactions of The Asme","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1115/1.4063357","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, MANUFACTURING","Score":null,"Total":0}
Design and Fabrication of In-house Nozzle System to Extrude Multi-Hydrogels for 3D Bioprinting Process
The field of 3D bio-printing is rapidly expanding as researchers strive to create functional tissues for medical and pharmaceutical purposes. The ability to print multiple materials, each containing various living cells, brings us closer to achieving tissue regeneration. In a previous study, we designed a Y-shaped nozzle connector system that allowed for continuous deposition of multiple materials. This system was made of plastic and had a fixed switching angle, rendering it suitable for a single use. In this paper, we present the updated version of our nozzle system, which includes a range of angles (30°, 45°, 60°, and 90° degrees) between the two materials. We used stainless steel as the fabrication material and recorded the overall material switching time, comparing the effects of the various angles. Our previously developed hybrid hydrogel, which comprised 4% Alginate and 4% Carboxymethyl Cellulose (CMC), was used as a test material to flow through the nozzle system. The in-house fabricated nozzle connectors are reusable, sterile, and easy to clean, ensuring a smooth material transition and flow.
期刊介绍:
Areas of interest including, but not limited to: Additive manufacturing; Advanced materials and processing; Assembly; Biomedical manufacturing; Bulk deformation processes (e.g., extrusion, forging, wire drawing, etc.); CAD/CAM/CAE; Computer-integrated manufacturing; Control and automation; Cyber-physical systems in manufacturing; Data science-enhanced manufacturing; Design for manufacturing; Electrical and electrochemical machining; Grinding and abrasive processes; Injection molding and other polymer fabrication processes; Inspection and quality control; Laser processes; Machine tool dynamics; Machining processes; Materials handling; Metrology; Micro- and nano-machining and processing; Modeling and simulation; Nontraditional manufacturing processes; Plant engineering and maintenance; Powder processing; Precision and ultra-precision machining; Process engineering; Process planning; Production systems optimization; Rapid prototyping and solid freeform fabrication; Robotics and flexible tooling; Sensing, monitoring, and diagnostics; Sheet and tube metal forming; Sustainable manufacturing; Tribology in manufacturing; Welding and joining