多发性硬化患者血清幽门螺杆菌检测

IF 0.4 Q4 NEUROSCIENCES

Archives of Neuroscience Pub Date : 2023-08-06 DOI:10.5812/ans-133607

M. Meshkat, Yeganeh Behjati, Mansooreh Bakhshi, Z. Meshkat, Mina Yazdan Mehr, R. Boostani, M. Saeidi, M. Khoshakhlagh, Amin Hooshyar Chechaklou, Mahya Najjari, Samaneh Abolbashari, A. Gholoubi

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引用次数: 0

摘要

背景：多发性硬化症（MS）是一种病因不明的中枢神经系统自身免疫性炎症性疾病，被认为是由遗传和环境因素引发的免疫失调引起的，导致脱髓鞘和轴突丢失。研究人员将幽门螺杆菌等传染源视为这些环境因素。幽门螺杆菌可以永久感染某人的胃，并引起急性或慢性炎症反应，其中炎症介质会影响大脑并导致病理疾病。方法：在这项横断面研究中，纳入了38名转诊至盖姆医院神经科诊所的多发性硬化症患者，并使用酶联免疫吸附试验（ELISA）分析了他们的血清样本中抗幽门螺杆菌的IgM、IgA和IgG抗体。结果与加埃姆医院其他病房收治的41名性别和年龄匹配且没有MS症状的对照组样本进行了比较。最后，我们用SPSS v.20对数据进行了分析。结果：在本研究中，对79名患者进行了研究，其中病例组为38名MS患者，对照组为41名健康人。这两组在人口统计学特征上没有显著差异，包括年龄、性别和职业。MS患者的幽门螺杆菌血清阳性率显著高于对照组（68.4%vs 39%）（P=0.009）。此外，比较30例复发-缓解型MS患者中20例的幽门螺杆杆菌血清阳性率与8例进行性MS患者中6例的幽门螺旋菌血清阳性度，表明这两组之间存在显著差异（P=0.030），幽门螺杆菌血清阳性在男性和女性之间没有显著差异（39.1%vs 58.9%），提示幽门螺杆菌可能是发展和进展为多发性硬化症的原因之一，这可能对预后和病程产生不利影响。

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Serum Evaluation of Helicobacter pylori in Patients with Multiple Sclerosis

Background: Multiple sclerosis (MS) is an autoimmune inflammatory disorder of the central nervous system of unknown etiology, which is believed to be caused by immune dysregulation triggered by genetic and environmental factors, leading to demyelination and axonal loss. Researchers consider infectious agents, like Helicobacter pylori, as these environmental factors. H. pylori can permanently infect someone’s stomach and cause an acute or chronic inflammatory response, in which inflammatory mediators affect the brain and cause a pathologic disease. Methods: In this cross-sectional study, 38 patients with multiple sclerosis who were referred to the Neurology Clinic of Ghaem Hospital were included, and their serum samples were analyzed for IgM, IgA, and IgG antibodies against H. pylori by using enzyme-linked immunosorbent assay (ELISA). Results were compared with the samples of 41 sex- and age-matched controls admitted to other wards of Ghaem Hospital & had no symptoms of MS. In the end, we analyzed the data with SPSS v.20. Results: In this study, 79 patients, including 38 patients with MS disease in the case group and 41 healthy individuals in the control group, were studied. These two groups had no significant differences in demographic characteristics, including age, gender, and occupation. H. pylori seropositivity was significantly higher in patients with MS than in controls (68.4% vs 39%) (P = 0.009). In addition, comparing H. pylori seropositivity in 20 of 30 patients with relapsing-remitting MS versus 6 of 8 patients with progressive MS suggested a significant difference between these two groups (P = 0.030). Also, H. pylori seropositivity had no significant difference between males and females (39.1% vs 58.9%). Conclusions: The prevalence of H. pylori seropositivity was significantly higher in patients with MS than in control, besides this seems more frequent in a progressive type of MS than in a relapsing-remitting one, suggesting that H. pylori might be a causal factor for developing & progressing MS and this may have an adverse impact on the prognosis and course of the disease.

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来源期刊

Archives of Neuroscience NEUROSCIENCES-

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期刊介绍： Archives of neuroscience is a clinical and basic journal which is informative to all practitioners like Neurosurgeons, Neurologists, Psychiatrists, Neuroscientists. It is the official journal of Brain and Spinal Injury Research Center. The Major theme of this journal is to follow the path of scientific collaboration, spontaneity, and goodwill for the future, by providing up-to-date knowledge for the readers. The journal aims at covering different fields, as the name implies, ranging from research in basic and clinical sciences to core topics such as patient care, education, procuring and correct utilization of resources and bringing to limelight the cherished goals of the institute in providing a standard care for the physically disabled patients. This quarterly journal offers a venue for our researchers and scientists to vent their innovative and constructive research works. The scope of the journal is as far wide as the universe as being declared by the name of the journal, but our aim is to pursue our sacred goals in providing a panacea for the intractable ailments, which leave a psychological element in the daily life of such patients. This authoritative clinical and basic journal was founded by Professor Madjid Samii in 2012.