N-（2-异烟酸肼基羰基）苯甲酰胺及其金属配合物的光谱、光学和细胞毒性研究

IF 1.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Heteroatom Chemistry Pub Date : 2018-06-04 DOI:10.1002/hc.21415

Nasser Mohammed Hosny, Heba M. Mahmoud, Mohamed H. Abdel-Rhman

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引用次数: 15

摘要

合成了配体N-(2-异烟碱酰肼-羰基)苯甲酰胺(H3L)及其与Co(II)、Ni(II)、Cu(II)、Zn(II)乙酸酯的金属配合物。通过元素分析、FT-IR、uv -可见光谱、1H-NMR、13C-NMR、ESR、MS、有效磁矩、摩尔电导和热分析对合成的化合物进行了表征。游离有机配体以酮形式存在，但在金属配合物中，它与烯醇形式的金属离子形成螯合物。测量的光学带隙(Eg)值证实了电流化合物的直接电子跃迁和半导体性的存在。该配体及其Zn(II)配合物对HePG-2和HCT-116具有细胞毒性。H3L表现出较强的细胞毒性，而Zn配合物表现出中等的活性。

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Spectral, optical, and cytotoxicity studies on N-(2-isonicotinoylhydrazine-carbonothioyl)benzamide and its metal complexes

The ligand N-(2-isonicotinoylhydrazine-carbonothioyl)benzamide (H₃L) and its metal complexes with Co(II), Ni(II), Cu(II), and Zn(II) acetates have been synthesized. The synthesized compounds have been characterized by elemental analyses, FT-IR, UV-Visible spectra, ¹H-NMR, ¹³C-NMR, ESR, MS, effective magnetic moments, molar conductance, and thermal analyses. The free organic ligand exists in the keto form, but in the metal complexes, it forms chelates with the metal ions in the enol form. The measured optical band gap (E_g) values confirmed the presence of direct electronic transition and the semiconductivity of the current compounds. The ligand and its Zn(II) complex were examined as cytotoxic agents against HePG-2 and HCT-116 and showed. H₃L exhibited strong cytotoxicity, while Zn complex showed moderate activity.

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来源期刊

Heteroatom Chemistry 化学-化学综合

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Heteroatom Chemistry brings together a broad, interdisciplinary group of chemists who work with compounds containing main-group elements of groups 13 through 17 of the Periodic Table, and certain other related elements. The fundamental reactivity under investigation should, in all cases, be concentrated about the heteroatoms. It does not matter whether the compounds being studied are acyclic or cyclic; saturated or unsaturated; monomeric, polymeric or solid state in nature; inorganic, organic, or naturally occurring, so long as the heteroatom is playing an essential role. Computational, experimental, and combined studies are equally welcome. Subject areas include (but are by no means limited to): -Reactivity about heteroatoms for accessing new products or synthetic pathways -Unusual valency main-group element compounds and their properties -Highly strained (e.g. bridged) main-group element compounds and their properties -Photochemical or thermal cleavage of heteroatom bonds and the resulting reactivity -Uncommon and structurally interesting heteroatom-containing species (including those containing multiple bonds and catenation) -Stereochemistry of compounds due to the presence of heteroatoms -Neighboring group effects of heteroatoms on the properties of compounds -Main-group element compounds as analogues of transition metal compounds -Variations and new results from established and named reactions (including Wittig, Kabachnik–Fields, Pudovik, Arbuzov, Hirao, and Mitsunobu) -Catalysis and green syntheses enabled by heteroatoms and their chemistry -Applications of compounds where the heteroatom plays a critical role. In addition to original research articles on heteroatom chemistry, the journal welcomes focused review articles that examine the state of the art, identify emerging trends, and suggest future directions for developing fields.