分子和血清学诊断检测的综合综述和临床指南及未来发展:COVID-19体外诊断检测

IF 6.1 3区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Yonrapach Areerob, Suresh Sagadevan, W. Oh
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引用次数: 1

摘要

摘要新冠肺炎是由SARS冠状病毒2(SARS-CoV-2)引起的一种传染性综合征,需要快速诊断检测来识别和管理受影响的人,确定流行病学特征,并及时做出公共卫生决策,管理受影响人身上存在的病毒,并通过流行病学特征及时做出公共健康决策。技术问题,特别是在手动实时聚合酶链式反应(RT-PCR)过程中发生的污染,可能导致NAAT结果呈假阳性。在某些情况下,RNA检测技术和抗原检测是RT-PCR的替代品。测序对于追踪严重急性呼吸系统综合征冠状病毒2型基因组的进化至关重要,而抗体检测对流行病学有益。严重急性呼吸系统综合征冠状病毒2型检测可以在不损失准确性的情况下变得更安全、更快、更容易。包括智能手机集成在内的持续技术进步将有助于应对当前的疫情,并为下一次疫情做好准备。纳米技术推动了卫生部门的进步,在早期阶段帮助了疾病和流行病的管理。这些基于纳米技术的分析工具可用于快速诊断新冠肺炎。SPOT系统用于快速、灵敏、准确、便携地诊断冠状病毒。SPOT检测包括RT-LAMP,然后是基于pfAgo的靶序列检测。此外,SPOT系统用于检测阳性和阴性的严重急性呼吸系统综合征冠状病毒2型样本。这种速度、精度、灵敏度和机动性的结合将使新冠肺炎检测具有成本效益和高容量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A comprehensive review and clinical guide to molecular and serological diagnostic tests and future development: In vitro diagnostic testing for COVID-19
Abstract COVID-19 is a contagious syndrome caused by SARS Coronavirus 2 (SARS-CoV-2) that requires rapid diagnostic testing to identify and manage in the affected persons, characterize epidemiology, and promptly make public health decisions and manage the virus present in the affected person and promptly make public health decisions by characterizing the epidemiology. Technical problems, especially contamination occurring during manual real-time polymerase chain reaction (RT-PCR), can result in false-positive NAAT results. In some cases, RNA detection technology and antigen testing are alternatives to RT-PCR. Sequencing is vital for tracking the SARS-CoV-2 genome’s evolution, while antibody testing is beneficial for epidemiology. SARS-CoV-2 testing can be made safer, faster, and easier without losing accuracy. Continued technological advancements, including smartphone integration, will help in the current epidemic and prepare for the next. Nanotechnology-enabled progress in the health sector has aided disease and pandemic management at an early stage. These nanotechnology-based analytical tools can be used to quickly diagnose COVID-19. The SPOT system is used to diagnose the coronavirus quickly, sensibly, accurately, and with portability. The SPOT assay consists of RT-LAMP, followed by pfAgo-based target sequence detection. In addition, SPOT system was used to detect both positive and negative SARS-CoV-2 samples. This combination of speed, precision, sensitivity, and mobility will allow for cost-effective and high-volume COVID-19 testing.
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来源期刊
Nanotechnology Reviews
Nanotechnology Reviews CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
11.40
自引率
13.50%
发文量
137
审稿时长
7 weeks
期刊介绍: The bimonthly journal Nanotechnology Reviews provides a platform for scientists and engineers of all involved disciplines to exchange important recent research on fundamental as well as applied aspects. While expert reviews provide a state of the art assessment on a specific topic, research highlight contributions present most recent and novel findings. In addition to technical contributions, Nanotechnology Reviews publishes articles on implications of nanotechnology for society, environment, education, intellectual property, industry, and politics.
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