18F-FDG PET/CT在预测非小细胞肺癌EGFR突变状态中的应用价值

中华核医学与分子影像杂志 Pub Date : 2019-10-25 DOI:10.3760/CMA.J.ISSN.2095-2848.2019.10.012

Guotao Yin, Wengui Xu, Xiaofeng Li

{"title":"18F-FDG PET/CT在预测非小细胞肺癌EGFR突变状态中的应用价值","authors":"Guotao Yin, Wengui Xu, Xiaofeng Li","doi":"10.3760/CMA.J.ISSN.2095-2848.2019.10.012","DOIUrl":null,"url":null,"abstract":"Lung cancer is a malignant tumor with the high morbidity and mortality in the world, and non-small cell lung cancer (NSCLC) is the most common type. The emergence of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in recent years has provided new treatment option for NSCLC patients. The efficacy of EGFR-TKI is closely related to the EGFR mutation status, but the current detection methods for gene mutation have certain limitations. As a non-invasive method, 18F-fluorodeoxyglucose (FDG) PET/CT shows a certain potential in the detection of EGFR gene mutation status. In this paper, the recent research and progress of PET/CT in predicting the mutation status of EGFR gene are reviewed. \n \nKey words: \nCarcinoma, non-small-cell lung; Mutation; Receptor, epidermal growth factor; Positron-emission tomography; Tomography, X-ray computed; Deoxyglucose; Trends","PeriodicalId":10099,"journal":{"name":"中华核医学与分子影像杂志","volume":"39 1","pages":"623-626"},"PeriodicalIF":0.0000,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Application value of 18F-FDG PET/CT in predicting EGFR mutation status in non-small cell lung cancer\",\"authors\":\"Guotao Yin, Wengui Xu, Xiaofeng Li\",\"doi\":\"10.3760/CMA.J.ISSN.2095-2848.2019.10.012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Lung cancer is a malignant tumor with the high morbidity and mortality in the world, and non-small cell lung cancer (NSCLC) is the most common type. The emergence of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in recent years has provided new treatment option for NSCLC patients. The efficacy of EGFR-TKI is closely related to the EGFR mutation status, but the current detection methods for gene mutation have certain limitations. As a non-invasive method, 18F-fluorodeoxyglucose (FDG) PET/CT shows a certain potential in the detection of EGFR gene mutation status. In this paper, the recent research and progress of PET/CT in predicting the mutation status of EGFR gene are reviewed. \\n \\nKey words: \\nCarcinoma, non-small-cell lung; Mutation; Receptor, epidermal growth factor; Positron-emission tomography; Tomography, X-ray computed; Deoxyglucose; Trends\",\"PeriodicalId\":10099,\"journal\":{\"name\":\"中华核医学与分子影像杂志\",\"volume\":\"39 1\",\"pages\":\"623-626\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-10-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华核医学与分子影像杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.2095-2848.2019.10.012\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华核医学与分子影像杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.2095-2848.2019.10.012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

肺癌是世界上发病率和死亡率都很高的恶性肿瘤，其中非小细胞肺癌(NSCLC)是最常见的类型。近年来表皮生长因子受体(EGFR)-酪氨酸激酶抑制剂(TKI)的出现为NSCLC患者提供了新的治疗选择。EGFR- tki的疗效与EGFR突变状态密切相关，但目前基因突变的检测方法存在一定的局限性。18F-fluorodeoxyglucose (FDG) PET/CT作为一种无创方法，在检测EGFR基因突变状态方面显示出一定的潜力。本文就近年来PET/CT在预测EGFR基因突变状态方面的研究进展进行综述。关键词:肺癌，非小细胞肺;突变;受体，表皮生长因子;正电子发射断层扫描;断层扫描，x射线计算机;脱氧葡萄糖;趋势

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Application value of 18F-FDG PET/CT in predicting EGFR mutation status in non-small cell lung cancer

Lung cancer is a malignant tumor with the high morbidity and mortality in the world, and non-small cell lung cancer (NSCLC) is the most common type. The emergence of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in recent years has provided new treatment option for NSCLC patients. The efficacy of EGFR-TKI is closely related to the EGFR mutation status, but the current detection methods for gene mutation have certain limitations. As a non-invasive method, 18F-fluorodeoxyglucose (FDG) PET/CT shows a certain potential in the detection of EGFR gene mutation status. In this paper, the recent research and progress of PET/CT in predicting the mutation status of EGFR gene are reviewed. Key words: Carcinoma, non-small-cell lung; Mutation; Receptor, epidermal growth factor; Positron-emission tomography; Tomography, X-ray computed; Deoxyglucose; Trends

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

中华核医学与分子影像杂志核医学，分子影像

自引率

0.00%

发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.