肉桂精油与百里酚、香芹酚、丁香酚或香叶醇组合的抗菌效果

IF 0.7 Q4 PHARMACOLOGY & PHARMACY
Y. El Atki, I. Aouam, A. Taroq, Fatima El Kamari, M. Timinouni, B. Lyoussi, A. Abdellaoui
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引用次数: 4

摘要

通过使用植物衍生物的天然产物来控制细菌对经典抗生素的耐药性是一个惊人的速度。本研究的目的是测定肉桂精油(EO)的植物化学成分,并评估其单独或与EO的一些主要成分(如百里酚、香芹酚、丁香酚或香叶醇)联合对三种细菌菌株(大肠杆菌、金黄色葡萄球菌和绿脓杆菌)的抗菌活性。采用气相色谱-火焰离子化检测器和气相色谱-质谱分析对肉桂EO的植物化学分析进行了评价。通过琼脂盘扩散和最小抑菌浓度(MIC)测定测试化合物的抗菌活性。棋盘格法用于量化肉桂EO与这些化合物组合的功效。结果表明,肉桂EO中的主要化合物为反式肉桂醛(91.01%),肉桂油对大肠杆菌、金黄色葡萄球菌和铜绿假单胞菌的MIC分别为0.005、0.005和0.02mg/mL,具有最高的抗菌活性。肉桂EO和百里酚的组合仅显示出对金黄色葡萄球菌的协同活性。当肉桂EO与百里香酚或香芹酚组合时,发现对大肠杆菌有加性作用,当肉桂EO和香芹酚结合时,发现了对金黄色葡萄球菌的加性作用。然而,EO和百里香酚或香芹酚的组合对铜绿假单胞菌表现出漠不关心的作用。肉桂EO与百里酚或香芹酚的组合可以用作医疗应用的替代治疗剂和天然防腐剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antibacterial effect of combination of cinnamon essential oil and thymol, carvacrol, eugenol, or geraniol
Bacterial resistance to classic antibiotics is an alarming rate to put this into control with the use of natural products of plant derivatives. The objective of this study was to determine the phytochemical of cinnamon essential oil (EO) and to evaluate its antibacterial activity alone and in combination with some main components of EOs such as thymol, carvacrol, eugenol, or geraniol against three bacterial strains (Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa). The phytochemical analysis of cinnamon EO was evaluated using gas chromatography-flame ionization detector and gas chromatography-mass spectrometer analysis. The antibacterial activity of tested compounds was determined by agar disk diffusion and minimum inhibitory concentration (MIC) assays. The checkerboard method was used to quantify the efficacy of cinnamon EO in combination with those compounds. The results showed that the major compound in the cinnamon EO was trans-cinnamaldehyde (91.01%). Cinnamon oil was the highest antibacterial activity with MIC of 0.005, 0.005, and 0.02 mg/mL against E. coli, S. aureus, and P. aeruginosa, respectively. Synergistic activity was shown only against S. aureus by the combination of cinnamon EO and thymol. The additive effect was found against E. coli when cinnamon EO was combined with thymol or carvacrol, and against S. aureus when cinnamon EO was combined with carvacrol. However, the combination of EO and thymol or carvacrol showed an indifference action against P. aeruginosa. The combination of cinnamon EO with thymol or carvacrol can be used as an alternative therapeutic agent for medical application and as a natural preservative.
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来源期刊
Journal of Reports in Pharmaceutical Sciences
Journal of Reports in Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.40
自引率
0.00%
发文量
0
期刊介绍: The Journal of Reports in Pharmaceutical Sciences(JRPS) is a biannually peer-reviewed multi-disciplinary pharmaceutical publication to serve as a means for scientific information exchange in the international pharmaceutical forum. It accepts novel findings that contribute to advancement of scientific knowledge in pharmaceutical fields that not published or under consideration for publication anywhere else for publication in JRPS as original research article. all aspects of pharmaceutical sciences consist of medicinal chemistry, molecular modeling, drug design, pharmaceutics, biopharmacy, pharmaceutical nanotechnology, pharmacognosy, natural products, pharmaceutical biotechnology, pharmacology, toxicology and clinical pharmacy.
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