早期癌症十大研究重点:加拿大以患者为导向的优先设定伙伴关系

CMAJ open Pub Date : 2022-01-01 DOI:10.9778/cmajo.20210046
C. Cuthbert, N. Nixon, M. Vickers, S. Samimi, K. Rawson, R. Ramjeesingh, S. Karim, B. Stein, Garry Laxdal, Lorilee Dundas, Diane Huband, Emily Dazé, C. Farrer, W. Cheung
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引用次数: 3

摘要

背景:结直肠癌是最常见的癌症之一,现在发现得更早,治疗方法也在改进,这意味着患者的寿命更长。我们与加拿大临床医生、患者和研究人员合作,旨在确定加拿大早期结直肠癌患者的研究重点。方法:我们遵循詹姆斯·林德联盟(James Lind Alliance)制定的确定重点的合作伙伴关系,以确定早期(即I-III期)结直肠癌未解决的问题并对其进行优先排序。该研究于2018年9月至2020年9月进行。我们在2019年6月至2019年12月期间对加拿大各地的患者、护理人员和临床医生进行了调查。我们使用主题分析对回答进行分类,以生成独特问题列表。我们在2020年4月至2020年7月期间对患者、护理人员和临床医生进行了一项临时优先级调查,以确定较短的问题清单,然后在2020年9月的最终会议(涉及患者、护理人员和临床医生)上进行了审查。在那次会议上,我们采用了基于共识的程序来确定十大优先事项。结果:在最初的调查中,185个人提交了370份回复;在提供人口统计信息的98个人中,44人(45%)是患者,16人(16%)是护理人员,7人(7%)是倡导团体的成员,26人(27%)是卫生保健专业人员,5人(5%)被归类为“其他”。这些回答经过提炼,形成了一个由66个独特的未回答问题组成的清单。25名受访者回答了中期优先调查:13名患者(52%),2名护理人员(8%),3名倡导小组成员(12%)和7名卫生保健专业人员(28%)。这导致了前30个问题的列表。最终的共识会议涉及20个人(10名患者[50%],3名护理人员[15%]和7名卫生保健专业人员[35%]),他们同意前10个研究重点。优先事项涵盖一系列主题,包括筛查、治疗、复发、不良反应管理和决策。解释:我们利用来自加拿大各地的利益相关者的合作伙伴关系确定了早期结直肠癌的研究重点。优先事项涵盖了未来研究可以解决的广泛主题,包括改进筛查做法、个性化医疗的作用、治疗不良反应的管理、决策和预防复发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Top 10 research priorities for early-stage colorectal cancer: a Canadian patient-oriented priority-setting partnership
Background: Colorectal cancer, one of the most commonly diagnosed cancers, is now being detected earlier and treatments are improving, which means that patients are living longer. Partnering with Canadian clinicians, patients and researchers, we aimed to determine research priorities for those living with early-stage colorectal cancer in Canada. Methods: We followed the well-established priority-setting partnership outlined by the James Lind Alliance to identify and prioritize unanswered questions about early-stage (i.e., stages I–III) colorectal cancer. The study was conducted from September 2018 to September 2020. We surveyed patients, caregivers and clinicians from across Canada between June 2019 and December 2019. We categorized the responses using thematic analysis to generate a list of unique questions. We conducted an interim prioritization survey from April 2020 to July 2020, with patients, caregivers and clinicians, to determine a shorter list of questions, which was then reviewed at a final meeting (involving patients, caregivers and clinicians) in September 2020. At that meeting, we used a consensus-based process to determine the top 10 priorities. Results: For the initial survey, 370 responses were submitted by 185 individuals; of the 98 individuals who provided demographic information, 44 (45%) were patients, 16 (16%) were caregivers, 7 (7%) were members of an advocacy group, 26 (27%) were health care professionals and 5 (5%) were categorized as “other.” The responses were refined to create a list of 66 unique unanswered questions. Twenty-five respondents answered the interim prioritization survey: 13 patients (52%), 2 caregivers (8%), 3 advocacy group members (12%) and 7 health care professionals (28%). This led to a list of the top 30 questions. The final consensus meeting involved 20 individuals (10 patients [50%], 3 caregivers [15%] and 7 health care professionals [35%]), who agreed to the top 10 research priorities. The priorities covered a range of topics, including screening, treatment, recurrence, management of adverse effects and decision-making. Interpretation: We determined the top research priorities for early-stage colorectal cancer using a collaborative partnership of stake-holders from across Canada. The priorities covered a broad range of topics that could be addressed by future research, including improved screening practices, the role of personalized medicine, the management of adverse effects of treatment, decision-making and prevention of recurrence.
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