A. El Mallah, M. Afify, Mohammed Abdel-Halim, Amr Mohammed
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引用次数: 0
摘要
背景与目的巨细胞病毒(CMV)传播到血清阴性且免疫力不足的患者可能会导致严重的后果。该研究的目的是确定Kafr El Sheikh总医院健康献血者中巨细胞病毒抗体的流行情况。患者和方法本研究纳入了100例具有相同纳入和排除标准的患者,年龄在18至60岁之间,确认丙型肝炎病毒、乙型肝炎病毒和艾滋病毒血清阴性。所有患者均被要求完成病史记录、全面临床检查、实验室评估和外周血样本。从每个人身上采集血样,检测巨细胞病毒免疫球蛋白G (IgG)和免疫球蛋白M (IgM)抗体。另一份样本取自igm阳性病例,以便对巨细胞病毒DNA进行PCR检测。结果研究组所有病例CMV IgG阳性,阳性率高达100%。因此,在Kafr El Sheikh的综合医院,健康献血者巨细胞病毒IgG的流行率很高。然而,其中有3例(3%)患者CMV IgM阳性,97例(97%)患者CMV IgM阴性,这表明Kafr El Sheikh总医院的健康献血者CMV IgM罕见。结论巨细胞病毒的高血清阳性率是血库开发巨细胞病毒阴性血液制品的障碍;尽管如此,我们发现集中筛查一组特定的献血者将是实现这一目标的最佳途径。
Seroprevelance of cytomegalovirus in healthy blood donors in Kafr El Sheikh General Hospital
Background and aim Cytomegalovirus (CMV) transmission to seronegative patients with inadequate immunity might result in significant consequences. The goal of the study was to determine the prevalence of CMV antibodies in healthy blood donors at the Kafr El Sheikh General Hospital. Patients and methods This research enrolled 100patients with the same inclusion and exclusion criteria, in age ranging between 18 and 60 years, with confirmed seronegativity for hepatitis C virus, hepatitis B virus, and HIV. All patients were asked to complete history taking, full clinical examination, laboratory assessment, and peripheral blood samples. The blood samples were taken from each individual to test for CMV immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies. Another sample was taken from IgM-positive cases in order to do PCR testing for CMV DNA. Results All cases among the study group were showing a positive CMV IgG with a high rate up to (100%). Consequently, in the general hospital in Kafr El Sheikh, healthy blood donors had a significant prevalence of CMV IgG. While, there were three (3%) patients of them had positive CMV IgM and 97 (97%) patients of them had Negative CMV IgM, this indicates a rarity of CMV IgM in healthy blood donors at Kafr El Sheikh General Hospital. Conclusion The high seroprevelance of CMV is a barrier to developing blood products of seronegative CMV in blood banks; nonetheless, we found that concentrated screening of a specific group of blood donors would be the best way to achieve this goal.