{"title":"无溶剂条件下氯化镓催化合成用于Biginelli反应的3,4-二氢嘧啶酮","authors":"Haixin Yuan, Kehua Zhang, Jingjing Xia, Xianhai Hu, Shizhen Yuan","doi":"10.1080/23312009.2017.1318692","DOIUrl":null,"url":null,"abstract":"Abstract We describe the syntheses of 3,4-dihydropyrimidinones or analogous thioketones by a one-pot cyclocondensation of acetoacetates, aldehydes and urea or thiourea using gallium (III) chloride as catalyst under solvent-free conditions. The improved Biginelli reaction not only features a simple procedure, high yields and easy purification of production, but also the recycled catalyst could be directly reused for many times while the yields of reaction would not decrease.","PeriodicalId":10640,"journal":{"name":"Cogent Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23312009.2017.1318692","citationCount":"19","resultStr":"{\"title\":\"Gallium (III) chloride-catalyzed synthesis of 3,4-dihydropyrimidinones for Biginelli reaction under solvent-free conditions\",\"authors\":\"Haixin Yuan, Kehua Zhang, Jingjing Xia, Xianhai Hu, Shizhen Yuan\",\"doi\":\"10.1080/23312009.2017.1318692\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract We describe the syntheses of 3,4-dihydropyrimidinones or analogous thioketones by a one-pot cyclocondensation of acetoacetates, aldehydes and urea or thiourea using gallium (III) chloride as catalyst under solvent-free conditions. The improved Biginelli reaction not only features a simple procedure, high yields and easy purification of production, but also the recycled catalyst could be directly reused for many times while the yields of reaction would not decrease.\",\"PeriodicalId\":10640,\"journal\":{\"name\":\"Cogent Chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/23312009.2017.1318692\",\"citationCount\":\"19\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cogent Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/23312009.2017.1318692\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cogent Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/23312009.2017.1318692","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Gallium (III) chloride-catalyzed synthesis of 3,4-dihydropyrimidinones for Biginelli reaction under solvent-free conditions
Abstract We describe the syntheses of 3,4-dihydropyrimidinones or analogous thioketones by a one-pot cyclocondensation of acetoacetates, aldehydes and urea or thiourea using gallium (III) chloride as catalyst under solvent-free conditions. The improved Biginelli reaction not only features a simple procedure, high yields and easy purification of production, but also the recycled catalyst could be directly reused for many times while the yields of reaction would not decrease.
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