坏死性下垂和焦亡信号通路概述

Q4 Immunology and Microbiology

中华微生物学和免疫学杂志 Pub Date : 2020-03-31 DOI:10.3760/CMA.J.CN112309-20190605-00176

Lixiang Chen, Shun Li, Xiaohui Zhou

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引用次数: 0

摘要

细胞死亡是生命周期中的重要事件。物理损伤可导致真核生物细胞死亡。此外，特异性信号通路介导的程序性细胞死亡也越来越受到关注。目前，细胞程序性死亡主要包括凋亡、程序性坏死(坏死下垂)和焦亡。坏死坏死和焦亡是细胞程序性死亡的两种新方式，在病原体感染过程中起着关键作用。necroptosis和pyroptosis都具有程序性溶解性细胞死亡的特征，但它们所涉及的信号通路有显著差异。本文就坏死下垂和焦下垂的形态学特征、信号转导途径及其在病原体感染过程中的作用作一综述。关键词:坏死性下垂;Pyroptosis;信号通路

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Overview of necroptosis and pyroptosis signaling pathways

Cell death is an important event in the life cycle. Physical injury can cause cell death in eukaryotes. Besides, specific signaling pathway-mediated programmed cell death has attracted increasing attention. Currently, programmed cell death mainly includes apoptosis, programmed necrosis (necroptosis) and pyroptosis. Necroptosis and pyroptosis, as two new ways of programmed cell death, have been found to play a key role in the process of pathogen infection. Both necroptosis and pyroptosis have the characteristics of programmed lytic cell death, but the signaling pathways involved in them have significant differences. This review focused on the morphological characteristics, signal transduction pathways and the role played in the process of pathogen infection of necroptosis and pyroptosis. Key words: Necroptosis; Pyroptosis; Signaling pathway

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来源期刊

中华微生物学和免疫学杂志 Immunology and Microbiology-Virology

CiteScore

0.50

自引率

0.00%

发文量

6906

期刊介绍： Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.