内窥镜泡沫硬化治疗内痔出血的疗效观察

中华消化内镜杂志 Pub Date : 2019-12-20 DOI:10.3760/CMA.J.ISSN.1007-5232.2019.12.009

F. Shen, C. Qu, Yi Zhang, Min Zhou, Zhen-ke Deng, Hua-ying Zhu, Jingyang Zhu, Guangjin Chen, Xi Zhang, Lei Xu

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引用次数: 1

摘要

目的评价泡沫硬化治疗内痔出血的安全性和有效性。方法前瞻性地纳入2017年3月至2018年3月期间连续发生痔疮出血的成年患者（年龄18-60岁）。所有患者被随机分为泡沫硬化治疗（FS）组和液体硬化治疗（LS）组。采用帽状结肠镜辅助泡沫液体硬化治疗痔疮核。结果共108例患者入选，其中男性62例（57.4%），平均年龄44.0±7.6岁。FS（n=55）组和LS（n=53）组在性别、年龄或体重指数方面没有显著差异。FS组月桂酸甘油酯注射液总量为3.7±0.9 mL，显著低于LS组（8.0±2.2 mL，P<0.001）。LS组有8例（15.1%）患者在拔针后出现出血，明显高于FS组[5.5%（3/53），P=0.022]。LS组2例（3.8%），FS组0例（P=0.025）出现明显疼痛。FS组的短期治愈率和有效率分别为87.3%（48/55）和9.1%（5/55），LS组分别为69.8%（37/53）和22.6%（12/53），结论泡沫硬化治疗出血性内痔安全有效。关键词：痔疮；硬化溶液；止血，内镜；硬化疗法

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Therapeutic effects of endoscopic foam sclerotherapy for bleeding internal hemorrhoids

Objective To evaluate the safety and efficacy of foam sclerotherapy for bleeding internal hemorrhoids. Methods Consecutive adult patients (aged 18-60 years) with bleeding hemorrhoids were prospectively enrolled between March 2017 and March 2018. All patients were randomly assigned to the foam sclerotherapy (FS) group and the liquid sclerotherapy (LS) group. The foam and liquid sclerotherapy of hemorrhoids nucleus was performed by cap-assisted colonic endoscopy. Results A total of 108 patients were enrolled, including 62 males (57.4%) with mean age of 44.0±7.6 years. There was no significant difference in gender, age, or body mass index between the FS (n = 55) group and the LS (n =53) group. The total amount of lauromacrogol injection in the FS group was 3.7±0.9 mL, which was significantly lower than that in the LS group (8.0±2.2 mL, P<0.001). In the LS group, 8 patients (15.1%) developed bleeding after needle removal, which was significantly higher than that in the FS group [5.5%(3/53), P=0.022]. Significant pain was found in 2 patients (3.8%) in the LS group and 0 in the FS group (P= 0.025). The short-term cure rate and effective rate of the FS group were 87.3% (48/55) and 9.1% (5/55), while those were 69.8% (37/53) and 22.6% (12/53) in the LS group, respectively (P=0.046). Conclusion Foam sclerotherapy is safe and effective in the treatment of bleeding internal hemorrhoids. Key words: Hemorrhoids; Sclerosing solutions; Hemostasis, endoscopic; Sclerotherapy

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来源期刊

中华消化内镜杂志

CiteScore

0.10

自引率

0.00%

发文量

7555

期刊介绍： Chinese Journal of Digestive Endoscopy is a high-level medical academic journal specializing in digestive endoscopy, which was renamed Chinese Journal of Digestive Endoscopy in August 1996 from Endoscopy. Chinese Journal of Digestive Endoscopy mainly reports the leading scientific research results of esophagoscopy, gastroscopy, duodenoscopy, choledochoscopy, laparoscopy, colorectoscopy, small enteroscopy, sigmoidoscopy, etc. and the progress of their equipments and technologies at home and abroad, as well as the clinical diagnosis and treatment experience. The main columns are: treatises, abstracts of treatises, clinical reports, technical exchanges, special case reports and endoscopic complications. The target readers are digestive system diseases and digestive endoscopy workers who are engaged in medical treatment, teaching and scientific research. Chinese Journal of Digestive Endoscopy has been indexed by ISTIC, PKU, CSAD, WPRIM.