Relevant factors of type 2 diabetic patients with cerebral infarction

Objective To investigate the relevant factors of type 2 diabetes mellitus(T2DM) with cerebral infarction(CI). Methods A total of 323 patients with T2DM from February 2012 to March 2017 in Inner Mongolia medical university affiliated hospital were included in this study. 150 patients with T2DM and CI were considered as experiment group, 173 cases of T2DM without CI were considered as control group. The clinical data of two groups were analyzed. Results The history of diabetes, smoking and hypertension were longer in experiment group than in control group (P<0.05). The patients in experiment group had higher fasting blood glucose(FBG), glycosylated hemoglobin(HbA1c), total triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, homocysteine(Hcy), fibrinogen(FIB), retinol binding protein 4(RBP4) and lower HDL-C, apolipoprotein A1(ApoA1) than the patients in control group(P<0.05). Multiple-factor logistic regression analysis showed that long-term smoking, long history of hypertension, high TG, high LDL-C, high non-HDL-C, high Hcy, high RBP4, low HDL-C and low ApoA1 were risk factors for CI in patients with T2DM (P<0.05). After adjusting common variables (diabetes history, hypertension history, smoking history, HbA1c, TG, TC), multiple-factor logistic regression analysis showed that LDL-C, non-HDL-C, Hcy, RBP4 were risk factors for CI in T2DM (P<0.05). HDL-C and ApoA1 were protective factors for CI in T2DM (P<0.05). Conclusion The risk factors for CI in patients with T2DM include long-term smoking, long hypertension history, high HbA1c, high TG, high LDL-C, high non-HDL-C, high Hcy, high RBP4, low HDL-C and low ApoA1. Patients should be advised to quit smoking, control blood glucose and blood pressure, and regulate blood lipid levels. Key words: Type 2 diabetes mellitus; Cerebral infarction; Relevant factors