右美托咪定对儿童七氟醚和地氟醚麻醉下出现谵妄及恢复参数的影响:一项双随机研究

IF 0.1 Q4 ANESTHESIOLOGY
R. Pandey, Jayaram A. Ankur Sharma, V. Darlong, R. Sinha, J. Punj, Sudershan Khokhar, A. Chowdhury, P. Singh
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引用次数: 0

摘要

背景:儿科患者突发性谵妄是家长焦虑增加的重要原因。儿童出现性谵妄的发生率主要根据所用麻醉剂的不同而不同。方法:本前瞻性、双盲、随机试验将152例1 ~ 6岁儿童在麻醉诱导后随机分为两组:S组使用七氟醚,D组使用地氟醚。S组患儿进一步随机分为S- Dex亚组(给予右美托咪定0.3 mcg/kg 5 ml生理盐水)和S- saline亚组(给予生理盐水5 ml)。同样,D组也随机分为两个亚组;D-Dex和D-Saline。我们比较围手术期血流动力学变量、术后出现谵妄、恢复情况、疼痛评分、抢救镇痛药需求和出院时间。结果:5、15、30 min时,S-Saline和D-Saline组出现谵妄的发生率明显高于S-Dex和D-Dex组。S-Saline组患者PAED、FLACC评分均显著高于S-Dex组,D-Saline组患者PAED、FLACC评分均显著高于D-Dex组(P<0.05)。S-Saline组需要镇痛的患者明显多于S-Dex组(P<0.05)。D-Saline组和D-Dex组镇痛效果无显著差异。(p = 0.153)。S-Dex组和D-Dex组出院时间明显长于S-Saline组和D-saline组。结论:右美托咪定可有效降低七氟醚和地氟醚麻醉下小儿手术患者出现谵妄和术后疼痛的发生率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of dexmedetomidine on emergence delirium and recovery parameters with sevoflurane and desflurane anaesthesia in children : a double randomized study
Background: Emergence delirium in pediatric patients is a significant cause of increased anxiety among parents. The incidence of emergence delirium in children varies mainly according to the anesthetic agents used. Methods: In this prospective, double-blind, randomized trial, 152 children of age group 1-6 years were randomized into two groups after induction of anesthesia: Group S received Sevoflurane, and Group D received Desflurane. Children in the S group were further randomized into subgroup S- Dex (receiving dexmedetomidine 0.3 mcg/kg in 5 ml saline) and subgroup S-Saline (receiving saline 5 ml). Similarly, Group D was also randomized into two subgroups; D-Dex and D-Saline. We compared perioperative hemodynamic variables, postoperative emergence delirium, recovery profile, pain scoring, the requirement of rescue analgesics, and time to discharge. Results: At 5, 15, and 30 minutes, the incidence of emergence delirium was significantly higher in S-Saline and D-Saline groups than S-Dex and D-Dex groups. Both PAED and FLACC scores were significantly higher in the S-Saline group than the S-Dex group and the D-Saline group compared to the D-Dex group (P<0.05). Significantly more patients required analgesia in the S-Saline group than in the S-Dex group (P<0.05). No significant difference for analgesia was present between D-Saline and D-Dex groups. (p = 0.153). Discharge time was significantly longer in S-Dex and D-Dex groups as compared to S-Saline and D-saline groups. Conclusions: Dexmedetomidine effectively reduced the incidence of emergence delirium and postoperative pain in pediatric patients undergoing surgery using Sevoflurane and Desflurane anesthesia.
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来源期刊
CiteScore
0.20
自引率
0.00%
发文量
2
期刊介绍: L’Acta Anaesthesiologica Belgica est le journal de la SBAR, publié 4 fois par an. L’Acta a été publié pour la première fois en 1950. Depuis 1973 l’Acta est publié dans la langue Anglaise, ce qui a été résulté à un rayonnement plus internationaux. Depuis lors l’Acta est devenu un journal à ne pas manquer dans le domaine d’Anesthésie Belge, offrant e.a. les textes du congrès annuel, les Research Meetings, … Vous en trouvez aussi les dates des Research Meetings, du congrès annuel et des autres réunions.
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