用于制药的高速喷射器

IF 0.8 4区医学 Q4 ENGINEERING, BIOMEDICAL

Journal of Medical Devices-Transactions of the Asme Pub Date : 2022-05-12 DOI:10.1115/1.4054549

Priyanka Hankare, Ashish Agrawala, V. Menezes

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引用次数: 0

摘要

开发并测试了一种冲击波驱动的无针注射器，用于将液体喷射输送到人造皮肤模型和猪皮样品中。该装置可以将足够体积的液体输送到足以使药物在皮肤样本中传播的深度。该装置配有防溅导管和消音器，以确保平稳运行。该概念有望通过a）最小限度地破坏皮肤中的血管，b）减少创伤、炎症并通过射流的液体帮助切割部位的再生，以及c）保留目标中的大部分微循环系统，从而实现有效的药物摄取，从而最大限度地减少液体注射的疼痛。推导并提出了预测射流侵彻粘弹性目标的理论模型。在实验射流穿透深度和相应的理论预测之间已经观察到了良好的一致性。该开发可以为免疫和药物递送提供一种成本效益高、微创的医疗保健解决方案。

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High-Speed Jet Injector for Pharmaceutical Applications

A shock wave-driven needle-free syringe was developed and tested for liquid jet delivery into an artificial skin model and porcine skin samples. The device could deliver an adequate volume of liquid to a depth sufficient for drug dissemination in skin samples. The device is equipped with a splash-proof conduit and a silencer for smooth operation. The concept is expected to minimize the pain of liquid injection by a) minimally breaching the blood vessels in the skin, b) reducing trauma, inflammation and aiding regeneration of the incised spot by the liquid of the jet, and c) preserving most of the micro-circulation system in the target, enabling an effective drug uptake. A theoretical model that predicts jet penetration into viscoelastic targets is derived and presented. A sound agreement has been observed between the experimental jet penetration depths and the corresponding theoretical predictions. The development can offer a cost-effective, minimally invasive health care solution for immunization and drug delivery.

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来源期刊

Journal of Medical Devices-Transactions of the Asme ENGINEERING, BIOMEDICAL-

CiteScore

1.80

自引率

11.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Medical Devices presents papers on medical devices that improve diagnostic, interventional and therapeutic treatments focusing on applied research and the development of new medical devices or instrumentation. It provides special coverage of novel devices that allow new surgical strategies, new methods of drug delivery, or possible reductions in the complexity, cost, or adverse results of health care. The Design Innovation category features papers focusing on novel devices, including papers with limited clinical or engineering results. The Medical Device News section provides coverage of advances, trends, and events.