利用Oncomine和Kaplan-Meier绘图仪检测卵巢癌中FOLR1的表达及预后

IF 0.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Qingyuan Su, Q. Lv, R. Wu
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引用次数: 0

摘要

摘要目的:通过对Oncomine和Kaplan-Meier数据库的深度挖掘,进一步探讨叶酸受体1 (FOLR1)基因在卵巢癌中的表达及其与患者预后的关系。方法:从Oncomine数据库中检索卵巢癌FOLR1 mRNA表达数据,并将肿瘤与健康组织进行对比分析。利用在线生存分析数据库Kaplan-Meier Plotter分析FOLR1在卵巢癌中的预后价值。结果Oncomine数据库共纳入了439项研究,涉及多种类型的癌症。在439项研究中,54项研究中FOLR1表达有统计学差异,19项研究中FOLR1表达升高,35项研究中FOLR1表达降低。在检索Oncomine数据库后,我们发现了6个比较卵巢肿瘤和健康组织mRNA表达的数据集。卵巢肿瘤组织中FOLR1 mRNA表达量显著高于正常卵巢组织(均p<0.05)。Kaplan-Meier Plotter数据库分析FOLR1表达与卵巢癌患者预后的相关性。卵巢癌患者FOLR1高、低表达组的无进展生存期差异有统计学意义(HR=1.14, 95%CI: 1.00-1.29, p=0.043)。然而,高、低FOLR1表达患者的总生存率无统计学差异(HR=0.95, 95%CI: 0.84-1.09, p=0.48)。结论与正常卵巢组织相比,FOLR1 mRNA在卵巢肿瘤中表达较高。FOLR1 mRNA表达升高与较差的无进展生存期相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mining expression and prognosis of FOLR1 in ovarian cancer by using Oncomine and Kaplan-Meier plotter
Abstract Objective: To further explore folate receptor 1 (FOLR1) gene expression in ovarian cancer and its association with patients’ prognosis by deep mining the Oncomine and Kaplan-Meier plotter databases. Methods: FOLR1 mRNA expression data of ovarian cancer were retrieved from the Oncomine database and further analyzed by comparing tumor to healthy tissue. The prognostic value of FOLR1 in ovarian cancer was analyzed by Kaplan-Meier Plotter, an online survival analysis database. Results A total of 439 studies were included in the Oncomine database in multiple types of cancers. Of the 439 studies, there were 54 with statistical differences for the expression of FOLR1, 19 with increased expression of FOLR1 and 35 with decreased expression comparing ovarian cancer to normal ovary tissue. After searching the Oncomine database, six datasets were discovered comparing the mRNA expression in ovarian tumor to healthy tissue. FOLR1 mRNA expression in ovarian tumor was significantly higher than that of normal ovarian tissue (all p<0.05). The Kaplan-Meier Plotter database analyzed the correlation between FOLR1 expression and ovarian cancer patient’s prognosis. A significant difference of progression-free survival between FOLR1 high and low expressing groups was found in ovarian cancer patients (HR=1.14, 95%CI: 1.00-1.29, p=0.043). However, the overall survival was not statistically different between high and low FOLR1 expressing patients (HR=0.95, 95%CI: 0.84-1.09, p=0.48). Conclusion FOLR1 mRNA was found to be highly expressed in ovarian tumor compared to normal ovarian tissue. Elevated FOLR1 mRNA expression was associated with the poor progression-free survival.
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来源期刊
Pteridines
Pteridines 生物-生化与分子生物学
CiteScore
1.20
自引率
25.00%
发文量
6
审稿时长
>12 weeks
期刊介绍: Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.
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