含有机硒配体的新型铂(II)配合物的合成及一些结构相关铂(II)配合物的细胞毒活性评价

IF 1.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Macedonian Journal of Chemistry and Chemical Engineering Pub Date : 2020-05-28 DOI:10.20450/mjcce.2020.1905

Ninko Radenković, M. Kostić, Nataša Đorđević, Z. Dolicanin, T. Soldatović, M. Zivanovic, V. Divac

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引用次数: 3

摘要

本文报道了新型反式双(2-苯基硒基甲基)氧烷二氯铂(II)配合物Pt1的合成。通过对HCT-116结直肠癌细胞系和MRC-5健康肺胸膜细胞系的体外研究，新合成的配合物与两个结构相关的反式pd (II)配合物(反式双(2-(苯基硒基甲基)氧烷)二氯alladium(II) Pd1和反式双(2-(苯基硒基甲基)氧烷)二氯alladium(II)) Pd2进行细胞毒活性筛选。通过与顺铂的比较来评估复合物的活性。MTT法测定细胞活力和增殖能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of New Pt(II) Complex Bearing Organoselenium Ligands and Evaluation of Cytotoxic Activity of Some Structurally Related Pd(II) Complexes

Herein we report the synthesis of new trans-bis(2-phenylselenylmethyl)oxolane)dichloroplatinum(II) complex Pt1. Newly synthetized complex, together with two, structurally related trans-Pd(II) complexes (trans-bis(2-(phenylselenylmethyl)oxolane)dichloropalladium(II) Pd1 and trans-bis(2-(phenylselenylmethyl)oxane)dichloropalladium(II)) Pd2, were screened for cytotoxic activity through in vitro study on the HCT-116 colorectal carcinoma cell line and on the MRC-5 healthy lung pleura cell line. Activity of complexes was assessed by comparing it to the cisplatin. The cells viability and proliferation were determined using MTT assay.

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来源期刊

Macedonian Journal of Chemistry and Chemical Engineering 化学-工程：化工

CiteScore

1.60

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： Macedonian Journal of Chemistry and Chemical Engineering (Maced. J. Chem. Chem. Eng.) is an official publication of the Society of Chemists and Technologists of Macedonia. It is a not-for-profit open acess journal published twice a year. The journal publishes original scientific papers, short communications, reviews and educational papers from all fields of chemistry, chemical engineering, food technology, biotechnology and material sciences, metallurgy and related fields. The papers published in the Journal are summarized in Chemical Abstracts.