阿托莫西汀与哌甲酯加氟西汀联合治疗多动症儿童焦虑症的随机临床试验

IF 0.5 Q4 PSYCHIATRY
A. Karbasi, S. Aghili
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引用次数: 0

摘要

背景:注意力缺陷/多动障碍(ADHD)是儿童时期最常见的精神障碍。并发焦虑症已经成为精神科医生面临的一个具有挑战性的问题。许多药物已经被应用,但反应有争议。目的:本研究旨在比较哌甲酯(MPH)和氟西汀(FLX)与阿托莫西汀(ATX)联合用药对伴有焦虑障碍的多动症儿童症状和功能的疗效。方法:对2020-2021年期间76名同时患有多动症和焦虑症的门诊儿童进行随机临床研究。病人被分成两组。第一组用MPH(5mg,每日两次)加FLX(10-20mg,每日);然而,第二组接受了剂量为1.4mg/kg的ATX。Conner父母评定量表(CPRS)、儿童焦虑相关情绪障碍筛查量表(SCARED)和儿童焦虑影响量表(CAIS-C)用于评估基线和干预后1个月和4个月的焦虑。结果:研究人群的平均年龄为9.26±1.92岁(范围:6-12岁),46名受试者(57.89%)为男性。无论对所有量表的评估采取何种干预措施,两组都有显著的改善趋势(所有量表均P<0.001);然而,两组的比较显示,CPRS(P=0.397)、SACRED(P=0.663)和CAIS-C(P=0.683)没有差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Atomoxetine Versus Combination of Methylphenidate Plus Fluoxetine for Management of Anxiety Disorders in ADHD Children: A Randomized Clinical Trial
Background: Attention-deficit/hyperactivity disorder (ADHD) is the most common psychiatric disorder in childhood. Concurrent anxiety disorders have turned into a challenging issue for psychiatrists. Numerous medications have been applied with controversial responses. Objectives: The current study aimed to compare the efficacy of the combination of methylphenidate (MPH) and fluoxetine (FLX) versus atomoxetine (ATX) in the symptoms and function of ADHD children with concurrent anxiety disorders. Methods: The current randomized clinical was conducted on 76 outpatient children with concurrent ADHD and anxiety disorder within 2020 - 2021. The patients were divided into two equal groups. The first group was treated with MPH (5 mg twice daily) plus FLX (10 - 20 mg daily); nevertheless, the second group received ATX with a dose of 1.4 mg/kg. The Conner’s Parents Rating Scale (CPRS), Screen for Child Anxiety Related Emotional Disorders (SCARED), and Children’s Anxiety Impact Scale-Child (CAIS-C) were applied to assess anxiety at the baseline and 1 month and 4 months after the interventions. Results: The mean age of the studied population was 9.26 ± 1.92 years (range: 6 - 12 years), and 46 subjects (57.89%) were male. The significant trends of improvement in both groups, regardless of the interventions in the assessments of all the scales, were noted (P < 0.001 for all the scales); however, the comparison of the groups revealed no differences in the CPRS (P = 0.397), SACRED (P = 0.663), and CAIS-C (P = 0.683). Conclusions: Based on the findings of this study, as ATX alone was as effective as MPH plus FLX for controlling anxiety disorders among ADHD children, ATX is preferred to apply fewer daily medications.
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来源期刊
CiteScore
1.20
自引率
10.00%
发文量
70
期刊介绍: The Iranian Journal of Psychiatry and Behavioral Sciences (IJPBS) is an international quarterly peer-reviewed journal which is aimed at promoting communication among researchers worldwide and welcomes contributions from authors in all areas of psychiatry, psychology, and behavioral sciences. The journal publishes original contributions that have not previously been submitted for publication elsewhere. Manuscripts are received with the understanding that they are submitted solely to the IJPBS. Upon submission, they become the property of the Publisher and that the data in the manuscript have been reviewed by all authors, who agree to the analysis of the data and the conclusions reached in the manuscript. The Publisher reserves copyright and renewal on all published material and such material may not be reproduced without the written permission of the Publisher. Statements in articles are the responsibility of the authors.
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