冠状病毒OC43感染过程中的反应性全身性血管炎1例

Benjamin Jacquet, V. Curiale, H. Mangeard, Émilie Ferrer, S. Chaillou
{"title":"冠状病毒OC43感染过程中的反应性全身性血管炎1例","authors":"Benjamin Jacquet, V. Curiale, H. Mangeard, Émilie Ferrer, S. Chaillou","doi":"10.4081/gc.2023.11295","DOIUrl":null,"url":null,"abstract":"This case report details a severe systemic failure following a coronavirus OC43 (HCoV-OC43) infection. A 78-year-old man, who had been vaccinated against SARS-CoV-2, was hospitalized for a flu-like infection and abdominal pain, revealing bilateral hemorrhagic adrenal infarctions with secondary adrenal failure. Imagery examinations showed adrenal necrosis and multiple ischemic cerebral strokes. A multiplex retro-transcriptase polymerase chain reaction (RT-PCR) became positive for HCoV-OC43. Cardio-vascular, infectious, and auto-immune exams were negative. A steroid medication finally allowed clinical improvement, and the diagnosis of reactional vasculitis was retained. An unknown pathogenicity of HCoV-OC43 is possible, considering that RT-PCR research is rarely made. The hypothesis of cross-reactions with SARS-CoV-2 antivaccine antibodies is also feasible. At last, the possible former virulence of HCoV-OC43 is being researched, in the event that this virus is connected to the 1889 Russian influenza pandemic. The development of multiplex RT-PCR would enable the study of other HCV-OC43 infections.","PeriodicalId":30930,"journal":{"name":"Geriatric Care","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reactive systemic vasculitis in the course of a coronavirus OC43 infection: a case report\",\"authors\":\"Benjamin Jacquet, V. Curiale, H. Mangeard, Émilie Ferrer, S. Chaillou\",\"doi\":\"10.4081/gc.2023.11295\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This case report details a severe systemic failure following a coronavirus OC43 (HCoV-OC43) infection. A 78-year-old man, who had been vaccinated against SARS-CoV-2, was hospitalized for a flu-like infection and abdominal pain, revealing bilateral hemorrhagic adrenal infarctions with secondary adrenal failure. Imagery examinations showed adrenal necrosis and multiple ischemic cerebral strokes. A multiplex retro-transcriptase polymerase chain reaction (RT-PCR) became positive for HCoV-OC43. Cardio-vascular, infectious, and auto-immune exams were negative. A steroid medication finally allowed clinical improvement, and the diagnosis of reactional vasculitis was retained. An unknown pathogenicity of HCoV-OC43 is possible, considering that RT-PCR research is rarely made. The hypothesis of cross-reactions with SARS-CoV-2 antivaccine antibodies is also feasible. At last, the possible former virulence of HCoV-OC43 is being researched, in the event that this virus is connected to the 1889 Russian influenza pandemic. The development of multiplex RT-PCR would enable the study of other HCV-OC43 infections.\",\"PeriodicalId\":30930,\"journal\":{\"name\":\"Geriatric Care\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Geriatric Care\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4081/gc.2023.11295\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Geriatric Care","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4081/gc.2023.11295","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

本病例报告详细描述了冠状病毒OC43(HCoV-OC43)感染后的严重系统性衰竭。一名78岁的男子接种了严重急性呼吸系统综合征冠状病毒2型疫苗,因流感样感染和腹痛住院,显示双侧出血性肾上腺梗死伴继发性肾上腺功能衰竭。影像学检查显示肾上腺坏死和多发性缺血性脑卒中。多重逆转录聚合酶链式反应(RT-PCR)对HCoV-OC43呈阳性反应。心血管、感染和自身免疫检查均为阴性。类固醇药物最终使临床得到改善,并保留了反应性血管炎的诊断。考虑到RT-PCR研究很少,HCoV-OC43的致病性可能未知。与严重急性呼吸系统综合征冠状病毒2型抗疫苗抗体发生交叉反应的假设也是可行的。最后,如果该病毒与1889年俄罗斯流感大流行有关,HCoV-OC43可能的前毒力正在研究中。多重RT-PCR的发展将使研究其他HCV-OC43感染成为可能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reactive systemic vasculitis in the course of a coronavirus OC43 infection: a case report
This case report details a severe systemic failure following a coronavirus OC43 (HCoV-OC43) infection. A 78-year-old man, who had been vaccinated against SARS-CoV-2, was hospitalized for a flu-like infection and abdominal pain, revealing bilateral hemorrhagic adrenal infarctions with secondary adrenal failure. Imagery examinations showed adrenal necrosis and multiple ischemic cerebral strokes. A multiplex retro-transcriptase polymerase chain reaction (RT-PCR) became positive for HCoV-OC43. Cardio-vascular, infectious, and auto-immune exams were negative. A steroid medication finally allowed clinical improvement, and the diagnosis of reactional vasculitis was retained. An unknown pathogenicity of HCoV-OC43 is possible, considering that RT-PCR research is rarely made. The hypothesis of cross-reactions with SARS-CoV-2 antivaccine antibodies is also feasible. At last, the possible former virulence of HCoV-OC43 is being researched, in the event that this virus is connected to the 1889 Russian influenza pandemic. The development of multiplex RT-PCR would enable the study of other HCV-OC43 infections.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
15
审稿时长
10 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信