登革热地方性对自动血液分析仪识别疟疾的影响——Beckman-Coulter LH750:一项基于医院的横断面研究

Reshma G. Kini, Nidhi Manoj, A. Amin, C. Moras, N. Marla
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引用次数: 0

摘要

目的:自动血液分析仪已被用于开发诊断疟疾的指标和算法。我们认为,这些指数的实际效用取决于社区中的感染情况,因为感染类型决定了血液学参数,从而决定了它们辨别疟疾的能力。我们地区是疟疾和登革热的地方病。我们的目的是验证已发表的疟疾因子(MF)在我们的环境中的效用。材料与方法:对临床疑似疟疾和登革热患者的抗凝血液进行分析。获得所有白细胞的标准偏差和平均值(M),并计算MF。结果:当对照组(CG)包括登革热阳性(DP)患者时,MF在识别疟疾方面的敏感性和特异性分别为75%和55.1%,当对照组不包括DP病例时,MF的敏感性和特异度分别为93.4%和65.2%。使用另一组参数,我们开发了一个疟疾判别指数,该指数在没有登革热的情况下识别疟疾的敏感性和特异性分别为94.4%和73.9%,在将登革热患者纳入CG的情况下,在1.26的情况下的敏感性和特异性分别为85.5%和61.7%。结论:本研究强调,在临床应用之前,需要验证在没有相似地方病特征的地区开发的指标/因素的效用,因为其他感染会影响判别能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of dengue endemicity on malaria identification by automated hematology analyzer – Beckman Coulter LH750: A hospital-based cross-sectional study
Aim: Automated hematology analyzers have been used to develop indices and algorithms for diagnosing malaria. We believe that the practical utility of such indices depends on the infection profile in the community since the type of infection determines the hematological parameters and consequently their power to discriminate malaria. Our region is endemic for malaria and dengue. Our aim was to verify the utility of the published malaria factor (MF) in our setting. Materials and Methods: Anticoagulated blood from clinically suspected cases of malaria and dengue were analyzed. The standard deviation and mean (M) values of all the leukocytes were obtained and the MF was calculated. Results: The MF showed a sensitivity and specificity of 75% and 55.1% in identifying malaria at a cutoff of 4.2 when the control group (CG) included dengue-positive (DP) patients and a sensitivity and specificity of 93.4% and 65.2% when the CG did not include DP cases. Using another set of parameters, we developed a Malaria Discriminant Index which showed a sensitivity and specificity of 94.4% and 73.9% in identifying malaria in the absence of dengue at a cutoff of 1.19 and a sensitivity and specificity of 85.5% and 61.7% at a cut off of 1.26 when dengue patients were included in the CG. Conclusion: This study emphasizes the need to verify the utility of indices/factors developed in regions not having similar endemic profiles before utilizing them in the clinical setting as other infections can influence the discriminant capacity.
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