Esther Klaver MD , Myrtle J. van der Wel MD , Sybren L. Meijer MD, PhD , Jacques J.G.H.M. Bergman MD, PhD , Roos E. Pouw MD, PhD
{"title":"第二章:Barrett食管及发育不良的病理证实","authors":"Esther Klaver MD , Myrtle J. van der Wel MD , Sybren L. Meijer MD, PhD , Jacques J.G.H.M. Bergman MD, PhD , Roos E. Pouw MD, PhD","doi":"10.1016/j.tgie.2018.03.002","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span>Barrett′s esophagus (BE) is a premalignant condition defined by the replacement of squamous epithelium by </span>columnar epithelium in the distal part of the esophagus. Patients with BE have an increased risk of progression to </span>esophageal adenocarcinoma<span><span> (EAC). Advanced EAC has a poor 5-year survival rate. However, if EAC is diagnosed at an early stage, endoscopic treatment has proven to be a safe and effective treatment, with excellent long-term survival rates. Currently it is not possible to accurately predict which patients with BE will develop EAC. Despite promising developments in genetic and molecular biomarker research, grade of </span>dysplasia is still the best predictor for progression to EAC. Present guidelines advise surveillance </span></span>endoscopies with biopsies for BE patients to detect early neoplasia at a treatable stage. Surveillance intervals are determined by length of the BE segment and on the histopathologic diagnosis of the biopsies. Accurate histopathologic assessment of biopsies to define surveillance intervals or to decide on a treatment strategy, is therefore of the utmost importance.</p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2018.03.002","citationCount":"0","resultStr":"{\"title\":\"Chapter 2: Role of pathologic confirmation for Barrett′s esophagus and dysplasia\",\"authors\":\"Esther Klaver MD , Myrtle J. van der Wel MD , Sybren L. Meijer MD, PhD , Jacques J.G.H.M. Bergman MD, PhD , Roos E. Pouw MD, PhD\",\"doi\":\"10.1016/j.tgie.2018.03.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span><span>Barrett′s esophagus (BE) is a premalignant condition defined by the replacement of squamous epithelium by </span>columnar epithelium in the distal part of the esophagus. Patients with BE have an increased risk of progression to </span>esophageal adenocarcinoma<span><span> (EAC). Advanced EAC has a poor 5-year survival rate. However, if EAC is diagnosed at an early stage, endoscopic treatment has proven to be a safe and effective treatment, with excellent long-term survival rates. Currently it is not possible to accurately predict which patients with BE will develop EAC. Despite promising developments in genetic and molecular biomarker research, grade of </span>dysplasia is still the best predictor for progression to EAC. Present guidelines advise surveillance </span></span>endoscopies with biopsies for BE patients to detect early neoplasia at a treatable stage. Surveillance intervals are determined by length of the BE segment and on the histopathologic diagnosis of the biopsies. Accurate histopathologic assessment of biopsies to define surveillance intervals or to decide on a treatment strategy, is therefore of the utmost importance.</p></div>\",\"PeriodicalId\":43887,\"journal\":{\"name\":\"Techniques in Gastrointestinal Endoscopy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.tgie.2018.03.002\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Techniques in Gastrointestinal Endoscopy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1096288318300184\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Techniques in Gastrointestinal Endoscopy","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1096288318300184","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Chapter 2: Role of pathologic confirmation for Barrett′s esophagus and dysplasia
Barrett′s esophagus (BE) is a premalignant condition defined by the replacement of squamous epithelium by columnar epithelium in the distal part of the esophagus. Patients with BE have an increased risk of progression to esophageal adenocarcinoma (EAC). Advanced EAC has a poor 5-year survival rate. However, if EAC is diagnosed at an early stage, endoscopic treatment has proven to be a safe and effective treatment, with excellent long-term survival rates. Currently it is not possible to accurately predict which patients with BE will develop EAC. Despite promising developments in genetic and molecular biomarker research, grade of dysplasia is still the best predictor for progression to EAC. Present guidelines advise surveillance endoscopies with biopsies for BE patients to detect early neoplasia at a treatable stage. Surveillance intervals are determined by length of the BE segment and on the histopathologic diagnosis of the biopsies. Accurate histopathologic assessment of biopsies to define surveillance intervals or to decide on a treatment strategy, is therefore of the utmost importance.
期刊介绍：
The purpose of each issue of Techniques in Gastrointestinal Endoscopy is to provide a comprehensive, current overview of a clinical condition or surgical procedure in gastrointestinal endoscopy, combining the effectiveness of an atlas with the timeliness of a journal. Each issue places a vigorous emphasis on diagnosis, rationale for and against a procedure, actual technique, management, and prevention of complications. The journal features abundant illustrations, line drawings and color artwork to guide readers through even the most complicated procedure.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
