三维点阵结构片剂溶出特性的研究

Q4 Engineering

Journal of the Korean Society for Precision Engineering Pub Date : 2023-08-31 DOI:10.7736/jkspe.023.002

Sang-Hoon Lee, Seung‐Min Oh, S. Park, Seok Kim, Y. Cho

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引用次数: 0

摘要

，采用点阵结构插入片剂，比较其溶出度。本研究提出的片剂可以通过FDM方法制备，采用具有较大表面积体积比的点阵结构。采用水溶性PVA长丝制备了具有不同晶格结构的片剂，并在37℃的水中进行了溶解实验，结果证实了其比表面积和质量损失率与三维晶格结构和整体结构均成正比。在不同结构中，金刚石结构的溶解活性最强

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A Study on the Dissolution Characteristics of 3D Printed Tablet with Lattice Structures

, a lattice structure was inserted into the tablet and the dissolution rate was compared. The tablet proposed in this study can be manufactured by the FDM method, adopting a lattice structure with a large surface area-to-volume ratio. Tablets containing various lattice structures were fabricated using water-soluble PVA filaments and dissolution experiments were conducted in water at 37 o C. As a result, it was confirmed that the specific surface area and the mass loss rate were proportional to both the 3D lattice structure and the monolith structure. Among different structures, the diamond structure had the most active dissolution

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来源期刊

Journal of the Korean Society for Precision Engineering Engineering-Industrial and Manufacturing Engineering

CiteScore

0.50

自引率

0.00%

发文量

104

期刊介绍： Journal of the Korean Society for Precision Engineering (JKSPE) is devoted to publishing original research articles with high ethical standard on all aspects of precision engineering and manufacturing. Specifically, the journal focuses on articles related to improving the precision of machines and manufacturing processes through implementation of creative solutions that stem from advanced research using novel experimental methods, predictive modeling techniques, and rigorous analyses based on mechanical engineering or multidisciplinary approach. The expected outcomes of the knowledge disseminated from JKSPE are enhanced reliability, better motion precision, higher measurement accuracy, and sufficient reliability of precision systems. The various topics covered by JKSPE include: Precision Manufacturing processes, Precision Measurements, Robotics and Automation / Control, Smart Manufacturing System, Design and Materials, Machine Tools, Nano/Micro Technology, Biomechanical Engineering, Additive Manufacturing System, Green Manufacturing Technology.