髓源性抑制细胞与血液恶性疾病

国际输血及血液学杂志 Pub Date : 2019-01-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.01.013

P. Dong

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引用次数: 0

摘要

髓源性抑制细胞（MDSC）是一组异质性的未成熟髓细胞，通过不同的机制抑制先天和适应性免疫系统，并在炎症、癌症和自身免疫性疾病等病理条件下积累。它在癌症的发展和免疫逃避中发挥作用。据报道，MDSC在血液系统恶性疾病中的数量增加，如白血病和淋巴瘤等，并与不良的临床结果有关。本综述旨在综述MDSC在血液系统恶性肿瘤中的病理生理机制以及MDSC在异基因造血干细胞移植（allo-HSCT）中的作用。关键词：骨髓源性抑制细胞；血液系统恶性肿瘤；白血病；淋巴瘤；免疫疗法

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Myeloid-derived suppressor cells and hematologic malignant diseases

Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immature myeloid cells that suppress the innate and adaptive immune system via different mechanisms and accumulate under pathological conditions, such as inflammation, cancer and autoimmune disease. It plays a role in the progression of cancer and immune evasion. Increased number of MDSC has been reported in hematologic malignant diseases, such as leukemia and lymphoma and so on, and is associated with a poor clinical outcome. This review aims to review the advance in pathophysiological mechanism of MDSC in hematologic malignancies and the role of MDSC in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Key words: Myeloid-derived suppressor cells; Hematologic malignancy; Leukemia; Lymphoma; Immunotherapy

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来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.