Netarsudil-associated reversible “honeycomb” pattern corneal epithelial edema

Netarsudil (Rho-associated protein kinase inhibitor) is one of the newer anti-glaucoma medications used for the management of glaucoma. It has the most common side effects, such as conjunctival hyperemia, subconjunctival hemorrhage, and cornea verticillata. This manuscript focuses on a rarer side effect of netarsudil-associated reticular corneal epithelial edema, after netarsudil application for 3 months in a 62-year-old male. This side effect is rarely reported in the literature. In this manuscript, netarsudil-associated reversible corneal epithelial edema and its management have been reported.