谷氨酸棒杆菌在l-苏氨酸生物合成中的应用

IF 3.3 3区农林科学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Fermentation-Basel Pub Date : 2023-09-08 DOI:10.3390/fermentation9090822

Min Duan, Shuo Chen, Xinli Liu, Jianhang Liu, Deqiang Zhu

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引用次数: 0

摘要

l-苏氨酸是人体和动物营养中的必需氨基酸。广泛应用于食品、医药、饲料等领域。全球市场规模超过每年70万吨。谷氨酸棒杆菌作为工业氨基酸生产的底盘细胞，具有生物安全性和较强的环境适应性等优点，是高效生产l-苏氨酸的潜在菌株。本文系统综述了l-苏氨酸的功能和应用，谷氨酸棒杆菌合成l-苏氨酸途径，以及利用代谢工程技术提高l-苏氨酸产量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Application of Corynebacterium glutamicum in l-Threonine Biosynthesis

l-threonine is an essential amino acid in human and animal nutrition. It is widely used in food, medicine, feed, and other fields. The global market scale exceeds 700,000 tons per year. Corynebacterium glutamicum, as a chassis cell for industrial amino acid production, has the advantages of biological safety and strong environmental adaptability, and is a potential strain for the efficient production of l-threonine. This article systematically reviewed the function and application of l-threonine, the pathway of C. glutamicum to synthesize l-threonine, and the use of metabolic engineering technology to improve the production of l-threonine.

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来源期刊

Fermentation-Basel BIOTECHNOLOGY & APPLIED MICROBIOLOGY-

CiteScore

3.80

自引率

18.90%

发文量

594

审稿时长

7 weeks