A Prospective, Randomized, Double Blind Study to Evaluate and Compare the Efficacy of Lidocaine, Granisetron and Magnesium Sulphate Pre-Medication, along with Venous Occlusion, in Attenuating the Pain caused due to Propofol Injection

A total of 150 male and female, adult patients, aged between 21-51 years, belonging to ASA grade I and II, of either sex, undergoing elective surgery under general anesthesia, were taken up for the study and randomly allocated to any of the 3 study groups of 50 patients each, using sealed envelopes. Along with venous occlusion at 50mm Hg for all patients, Group 1 patients received lidocaine 40mg pre-medication; group 2 patients received granisetron 2mg pre-medication while group 3 patients received magnesium sulphate 2.03mmol pre-medication. The demographic parameters (age, sex, ASA grading and presence of co-morbidities) were comparable in all the 3 groups. All the 3 drugs showed statistically significant results in causing pain attenuation at 0, 5, 10, 15 and 20 seconds of propofol injection. The overall order of efficacy of the 3 study drugs on the basis of reduction in the severityof propofol injection pain was: lidocaine > Granisetron > Magnesium sulphate.