表面增强拉曼光谱法对唾液和尿液中多种兴奋剂的超灵敏快速检测

IF 1.1 4区 化学 Q3 SPECTROSCOPY
Di Feng, Shan-shan Xu, Bao‐Ying Wen, M. Kathiresan, Yue-jiao Zhang, An Wang, Fan-Li Zhang, Shangzhong Jin, Jian‐Feng Li
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引用次数: 2

摘要

兴奋剂滥用是影响全球竞技体育的严重问题之一。传统的兴奋剂检测分析方法面临着成本高、体积大、预处理复杂以及检测时间长的挑战。因此,实现兴奋剂的现场快速检测至关重要。在此,我们提出了一种使用液相提取和表面增强拉曼光谱相结合的超灵敏和快速检测多种掺杂的策略。盐酸克仑特罗、美沙酮、羟考酮和氯二氮卓是四种兴奋剂,使用上述方法可以方便地在人类唾液和尿液中检测。唾液中克伦特罗、美沙酮、羟考酮和氯二氮卓的检测限分别为25、10、50和25 ng/mL,尿液中分别为25、5、50和25 ng/mL。最后,在大约一分钟内,四次浓度为100 可以准确、同步地检测唾液和尿液中的ng/mL。这种同步检测策略进一步证明了SERS在多种药物的现场快速检测方面的巨大优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ultrasensitive and rapid detection for multiple dopings in saliva and urine using surface-enhanced Raman spectroscopy
Abstract Abuse of dopings is one of the serious issues affecting competitive sports globally. Traditional means of analysis for doping detection face the challenges of costly, bulky, and complicated pretreatment, as well as long detection times. Therefore, it is critical to achieve on-site and rapid detection for dopings. Herein, we proposed a strategy for ultrasensitive and quick detection of multiple dopings using a combination of liquid phase extraction and surface-enhanced Raman spectroscopy. The clenbuterol, methadone, oxycodone, and chlordiazepoxide were four dopings, which could be detected conveniently in human saliva and urine using the above approach. The limit of detection for clenbuterol, methadone, oxycodone, and chlordiazepoxide in saliva were 25, 10, 50, and 25 ng/mL, respectively, and in urine, 25, 5, 50, and 25 ng/mL. Finally, in about a minute, four dopings at concentration of 100 ng/mL in saliva and urine can be detected accurately and synchronously. This synchronous detection strategy further demonstrates the enormous advantages of SERS in on-site and rapid detection of multiple drugs.
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来源期刊
Spectroscopy Letters
Spectroscopy Letters 物理-光谱学
CiteScore
2.90
自引率
5.90%
发文量
50
审稿时长
1.3 months
期刊介绍: Spectroscopy Letters provides vital coverage of all types of spectroscopy across all the disciplines where they are used—including novel work in fundamental spectroscopy, applications, diagnostics and instrumentation. The audience is intended to be all practicing spectroscopists across all scientific (and some engineering) disciplines, including: physics, chemistry, biology, instrumentation science, and pharmaceutical science.
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