IL-23R基因多态性(rs10889677 A/C)与强直性脊柱炎和类风湿性关节炎易感性的相关性:试验序列分析的荟萃分析

IF 3.3 4区 医学 Q3 IMMUNOLOGY
Zhang Tao, Lingxiang Yu, Ming Shao, Ye Wu, Jinian Wang, Y. Deng, M. Ni, Xiaoya Sun, Yuting Chen, Shanshan Xu, Yubo Ma, Z. Shuai, F. Pan
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引用次数: 3

摘要

自身免疫性疾病是免疫系统对自身抗原失去耐受性的一类慢性疾病。本荟萃分析的目的是确定IL-23R多态性与强直性脊柱炎(AS)、类风湿关节炎(RA)等常见自身免疫性疾病之间是否存在相关性。方法检索截至2021年9月的相关文献,采用不同的效应模型进行meta分析。采用95%置信区间(95% CI)和比值比(OR)确定rs10889677 (A/C)多态性与AS和RA的关系。最后,为了提高结果的可靠性,我们还应用了试验序列分析(TSA),检索了全基因组关联研究(GWAS)中与自身免疫性疾病(AS, RA)相关的数据。结果共纳入31项研究。Rs10889677 (A/C)与一般个体AS、RA易感性显著相关(p < 0.05)。此外,等位基因a与白种人AS和RA存在相关性(p < 0.05)。AA基因型增加蒙古人自身免疫性疾病的风险。因此,TSA进一步证明了meta分析的稳健性。结论IL-23R (rs10889677 A/C) A等位基因是普通人群尤其是白种人AS和RA的危险基因。AA基因型增加蒙古人AS和RA的发病风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations between IL-23R gene polymorphism (rs10889677 A/C) and ankylosing spondylitis and rheumatoid arthritis susceptibility: A meta-analysis with trial sequential analysis
Abstract Objectives Autoimmune diseases are a kind of chronic diseases for which the immune system loses tolerance to autoantigens. This meta-analysis’ purpose is to determine whether there exists a correlation between IL-23R polymorphism and common autoimmune diseases like ankylosing spondylitis (AS) and rheumatoid arthritis (RA). Methods We searched the relevant literatures up to September 2021 and used different effect models for meta-analysis. 95% confidence interval (95% CI) and odds ratio (OR) were used to determine the relationship between rs10889677 (A/C) polymorphism and AS as well as RA. Finally, to promote the reliability of results, the trial sequential analysis (TSA) has also been applied and we searched the data related to autoimmune diseases (AS, RA) on genome-wide association studies (GWAS). Results Generally, 31 studies were included. Rs10889677 (A/C) was significantly correlated with the susceptibility to AS and RA among the general individuals (p < .05). Moreover, there existed a relevance between allele A and AS as well as RA in Caucasians (p < .05). AA genotype increased the risk of autoimmune diseases in Mongolians. As a result, the robustness of meta-analysis has further been proved by TSA. Conclusion IL-23R (rs10889677 A/C) A allele was a risk gene for AS and RA in the general population, especially in Caucasians. AA genotype increased the risk of AS and RA in Mongolians.
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来源期刊
Autoimmunity
Autoimmunity 医学-免疫学
CiteScore
5.70
自引率
8.60%
发文量
59
审稿时长
6-12 weeks
期刊介绍: Autoimmunity is an international, peer reviewed journal that publishes articles on cell and molecular immunology, immunogenetics, molecular biology and autoimmunity. Current understanding of immunity and autoimmunity is being furthered by the progress in new molecular sciences that has recently been little short of spectacular. In addition to the basic elements and mechanisms of the immune system, Autoimmunity is interested in the cellular and molecular processes associated with systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome, type I diabetes, multiple sclerosis and other systemic and organ-specific autoimmune disorders. The journal reflects the immunology areas where scientific progress is most rapid. It is a valuable tool to basic and translational researchers in cell biology, genetics and molecular biology of immunity and autoimmunity.
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