Doença de Marchiafava-Bignami: Uma Complicação Rara do Abuso do Álcool

DOI: 10.24950/Imagem/151/20/4/2020 history of illicit drug use. On initial assessment his mini mental state scale was 19/30, he was disorientated in time and place, with reduced speech output, psychomotor retardation, but with no focal signs. His blood pressure was normal and he had no fever. Cerebral computerized tomography revealed a callosal hypodensity and global atrophy, with no acute vascular lesions (Fig. 1A). Laboratory studies disclosed mild macrocytic anemia and elevated liver enzymes; renal, thyroid and liver function were normal; systemic inflammatory biomarkers and serum ethanol were negative. Abdominal ultrasonography showed signs of steatosis, with no splenomegaly or ascites. Brain magnetic resonance imaging (MRI) confirmed the callosal lesion, with restricted diffusion (Fig. 2B) and showed T2/FLAIR hyperintensities