新辅助化疗诱导的急性肾损伤对接受根治性膀胱切除术患者肿瘤学结果的影响：一项多中心回顾性研究。

IF 42.1 1区医学 Q1 ONCOLOGY

Journal of Clinical Oncology Pub Date : 2023-02-20 DOI:10.1200/jco.2023.41.6_suppl.573

N. Fujita, M. Momota, S. Hatakeyama, H. Ito, T. Yoneyama, Y. Hashimoto, K. Yoshikawa, C. Ohyama

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Multivariable Cox-proportional hazards regression analyses were performed to evaluate the impact of NAC-induced AKI on recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS). Results: The median age and follow-up period were 69 years and 62 months, respectively. Of the 398 patients, 66 (17%) developed AKI during NAC. The rates of <ypT2 and downstage in the AKI group were significantly lower than those in the non-AKI group (38% vs. 53%, P = 0.023; 53% vs. 69%, P = 0.013; respectively). After adjustment for age, performance status, cisplatin-based regimen, tumor grade, pathological T stage, pathological lymph-node involvement, and positive surgical margin, AKI was associated with shorter RFS (hazard ratio [HR] 1.619, P = 0.043), CSS (HR 1.727, P = 0.049), and OS (HR 1.848, P = 0.008). 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引用次数: 1

摘要

573背景：新辅助化疗（NAC）诱导的急性肾损伤（AKI）是癌症（MIBC）患者的常见并发症。尽管先前的研究报告称，癌症治疗期间的AKI与几种癌症的肿瘤结果不佳有关，但NAC诱导的AKI对MIBC患者肿瘤结果的影响仍不清楚。方法：这项回顾性研究包括398名患者，他们接受了2-4个周期的NAC，然后进行了根治性膀胱切除术（RC）。AKI是根据KDIGO标准定义的。患者被分为两组：在NAC期间出现AKI的患者（AKI组）和没有出现AKI（非AKI组。对NAC诱导的AKI对无复发生存期（RFS）、癌症特异性生存期（CSS）和总生存期（OS）的影响进行了多变量Cox比例危险回归分析。结果：中位年龄和随访期分别为69岁和62个月。398名患者中，66人（17%）在NAC期间出现AKI。AKI组本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Impact of neoadjuvant chemotherapy–induced acute kidney injury on oncological outcomes in patients who underwent radical cystectomy: A multicenter retrospective study.

573 Background: Neoadjuvant chemotherapy (NAC)-induced acute kidney injury (AKI) is a frequent complication in patients with muscle-invasive bladder cancer (MIBC). Although previous studies have reported that AKI during cancer treatment was associated with poor oncological outcomes in several cancers, the impact of NAC-induced AKI on oncological outcomes in patients with MIBC remains unclear. Methods: This retrospective study included 398 patients who received 2-4 cycles of NAC followed by radical cystectomy (RC). AKI was defined according to the KDIGO criteria. Patients were divided into two groups: patients who developed AKI during NAC (AKI group) and patients who did not (non-AKI group). Multivariable Cox-proportional hazards regression analyses were performed to evaluate the impact of NAC-induced AKI on recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS). Results: The median age and follow-up period were 69 years and 62 months, respectively. Of the 398 patients, 66 (17%) developed AKI during NAC. The rates of

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来源期刊

Journal of Clinical Oncology 医学-肿瘤学

CiteScore

41.20

自引率

2.20%

发文量

8215

审稿时长

2 months

期刊介绍： The Journal of Clinical Oncology serves its readers as the single most credible, authoritative resource for disseminating significant clinical oncology research. In print and in electronic format, JCO strives to publish the highest quality articles dedicated to clinical research. Original Reports remain the focus of JCO, but this scientific communication is enhanced by appropriately selected Editorials, Commentaries, Reviews, and other work that relate to the care of patients with cancer.