{"title":"2016年纳米比亚温得和克孕妇巨细胞病毒血清流行率","authors":"B. E. van der Colf, G. V. van Zyl, S. Mackenzie","doi":"10.7196/SAJOG.1441","DOIUrl":null,"url":null,"abstract":"Background. Seroprevalence of cytomegalovirus (CMV) is high in developing countries. However, a pregnant woman’s immunity does not necessarily protect her baby against congenital CMV infection. Objectives. To determine the seroprevalence of CMV among pregnant women attending a public antenatal clinic (Windhoek Central Hospital, Namibia) and subsequently determine the risk of vertical transmission and congenital CMV infection. Methods. Blood samples and demographic information were collected from 344 pregnant women (age range 15 - 48 years). Serum was tested for anti-CMV IgG and IgM using an automated chemiluminescence assay, and an ELISA was used to assess specific IgG avidity. Fisher’s exact test was used to determine associations among variables. Results. Seroprevalence of anti-CMV IgG was found to be 100% across the study population, with positive or grey-zone anti-CMV IgM results found in 11 women (3.2%). Specific IgG avidity was high in all cases. Neither maternal nor gestational age was positively associated with a positive or grey-zone IgM result. Parity was significantly associated with CMV IgM seroprevalence, with the highest level observed in women who had had one previous pregnancy. Conclusion. This was the first study to investigate seroprevalence of CMV in Namibia. Despite the high seroprevalence among pregnant women, the burden of congenital CMV infection may b e carried by infants in the Namibian population. This may contribute to long-term disabilities, especially sensorineural hearing loss. Further studies are needed to determine the prevalence of congenital CMV in Namibia.","PeriodicalId":49579,"journal":{"name":"South African Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2019-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7196/SAJOG.1441","citationCount":"4","resultStr":"{\"title\":\"Seroprevalence of cytomegalovirus among pregnant women in Windhoek, Namibia, 2016\",\"authors\":\"B. E. van der Colf, G. V. van Zyl, S. Mackenzie\",\"doi\":\"10.7196/SAJOG.1441\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background. Seroprevalence of cytomegalovirus (CMV) is high in developing countries. However, a pregnant woman’s immunity does not necessarily protect her baby against congenital CMV infection. Objectives. To determine the seroprevalence of CMV among pregnant women attending a public antenatal clinic (Windhoek Central Hospital, Namibia) and subsequently determine the risk of vertical transmission and congenital CMV infection. Methods. Blood samples and demographic information were collected from 344 pregnant women (age range 15 - 48 years). Serum was tested for anti-CMV IgG and IgM using an automated chemiluminescence assay, and an ELISA was used to assess specific IgG avidity. Fisher’s exact test was used to determine associations among variables. Results. Seroprevalence of anti-CMV IgG was found to be 100% across the study population, with positive or grey-zone anti-CMV IgM results found in 11 women (3.2%). Specific IgG avidity was high in all cases. Neither maternal nor gestational age was positively associated with a positive or grey-zone IgM result. Parity was significantly associated with CMV IgM seroprevalence, with the highest level observed in women who had had one previous pregnancy. Conclusion. This was the first study to investigate seroprevalence of CMV in Namibia. Despite the high seroprevalence among pregnant women, the burden of congenital CMV infection may b e carried by infants in the Namibian population. This may contribute to long-term disabilities, especially sensorineural hearing loss. Further studies are needed to determine the prevalence of congenital CMV in Namibia.\",\"PeriodicalId\":49579,\"journal\":{\"name\":\"South African Journal of Obstetrics and Gynaecology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2019-11-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.7196/SAJOG.1441\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"South African Journal of Obstetrics and Gynaecology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7196/SAJOG.1441\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"South African Journal of Obstetrics and Gynaecology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7196/SAJOG.1441","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Seroprevalence of cytomegalovirus among pregnant women in Windhoek, Namibia, 2016
Background. Seroprevalence of cytomegalovirus (CMV) is high in developing countries. However, a pregnant woman’s immunity does not necessarily protect her baby against congenital CMV infection. Objectives. To determine the seroprevalence of CMV among pregnant women attending a public antenatal clinic (Windhoek Central Hospital, Namibia) and subsequently determine the risk of vertical transmission and congenital CMV infection. Methods. Blood samples and demographic information were collected from 344 pregnant women (age range 15 - 48 years). Serum was tested for anti-CMV IgG and IgM using an automated chemiluminescence assay, and an ELISA was used to assess specific IgG avidity. Fisher’s exact test was used to determine associations among variables. Results. Seroprevalence of anti-CMV IgG was found to be 100% across the study population, with positive or grey-zone anti-CMV IgM results found in 11 women (3.2%). Specific IgG avidity was high in all cases. Neither maternal nor gestational age was positively associated with a positive or grey-zone IgM result. Parity was significantly associated with CMV IgM seroprevalence, with the highest level observed in women who had had one previous pregnancy. Conclusion. This was the first study to investigate seroprevalence of CMV in Namibia. Despite the high seroprevalence among pregnant women, the burden of congenital CMV infection may b e carried by infants in the Namibian population. This may contribute to long-term disabilities, especially sensorineural hearing loss. Further studies are needed to determine the prevalence of congenital CMV in Namibia.
期刊介绍:
The SAJOG is a tri-annual, general specialist obstetrics and gynaecology journal that publishes original, peer-reviewed work in all areas of obstetrics and gynaecology, including contraception, urogynaecology, fertility, oncology and clinical practice. The journal carries original research articles, editorials, clinical practice, personal opinion, South Africa health-related news, obituaries and general correspondence.