甜菜根不同提取物对苯肼诱导大鼠抗氧化及抗贫血作用的研究

European Pharmaceutical Journal Pub Date : 2021-04-02 DOI:10.2478/afpuc-2020-0014

Ni Putu Ermi Hikmawanti, L. Dwita, Dimas W. Wisnunanda, Fanny Farista

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引用次数: 3

摘要

摘要目的评价甜菜根（Beta vulgaris（L.）subsp。vulgaris）对苯肼诱导的大鼠的作用。方法雄性大鼠分为5组：正常对照组、阴性对照组、二氯甲烷提取物组、无水乙醇提取物组和无生物碱无水乙醇提取物。除正常对照组外，所有组均用苯肼（30mg.Kg−1 BW）诱导三天。诱导后，每个治疗组接受每种提取物（200 mg.Kg−1 BW）21天。使用血液学分析仪测量血液学参数（血红蛋白水平、红细胞数量和红细胞比容水平），并通过大鼠MDA水平参数测量抗氧化活性。使用单因素方差分析对数据进行分析，然后继续进行Tukey检验。结果与阴性对照组相比，甜菜根水乙醇提取物使红细胞百分比（33.5%）、血红蛋白（25%）和红细胞压积（24.4%）增加，与正常对照组相当（p>0.05），结论甜菜根水乙醇粗提物可能作为一种具有抗贫血和抗氧化活性的有益资源在天然医药产品中生产。

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The Effect of Different Extracts of Beetroots as Antioxidant and Anti-Anaemia On Phenylhydrazine-Induced Rats

Abstract Aim evaluate antioxidant and anti-anaemia activity of dichloromethane, hydroethanolic, and alkaloids-free hydroethanolic extracts of beetroot (Beta vulgaris (L.) subsp. vulgaris) on phenylhydrazine-induced rats. Methods Male rats were divided into five groups: normal control group, negative control group, dichloromethane extract group, hydroethanolic extract group, and alkaloids-free hydroethanolic extract group. All groups were induced with phenylhydrazine (30 mg.Kg−1 BW) for three days, except for the normal control group. After induction, each treatment group received each extract (200 mg.Kg−1 BW) for 21 days. The haematology parameters (haemoglobin levels, the number of erythrocytes, and haematocrit levels) were measured using Haematology Analyzer, and the antioxidant activity was measured through MDA level parameters in rats. Data were analysed using one-way ANOVA and then continued with the Tukey test. Results The results showed that the hydroethanolic extract of beetroot increased the percentage of erythrocytes (33.5%), haemoglobin (25%), and haematocrit (24.4%) to the negative control group, which was comparable to the normal control group (p > 0.05). In addition, the best antioxidant activity was shown in the hydroethanolic extract of beetroot, which is comparable to the normal group (p > 0.05). Conclusion The beetroot hydroethanolic crude extract could be potentially produced in a natural pharmaceutical product as a beneficial resource within anti-anaemia and antioxidant activities.

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来源期刊

European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.