BRAFV600E和TERT启动子突变在甲状腺乳头状癌中共存的研究进展

中华核医学与分子影像杂志 Pub Date : 2019-10-25 DOI:10.3760/CMA.J.ISSN.2095-2848.2019.10.013

Y. Liu, Min Li, Qiuqin Qian, Peng Wen, F. Shi

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引用次数: 0

摘要

乳头状甲状腺癌(PTC)是最常见的甲状腺癌病理类型，其发病率在全球范围内迅速上升。V-raf鼠肉瘤病毒癌基因同源物B1 (BRAF)V600E突变和端粒酶逆转录酶(TERT)启动子突变是PTC最常见的分子标志物。如今，越来越多的研究发现BRAFV600E和TERT启动子突变共存对PTC的侵袭和预后具有协同作用。本文综述了BRAFV600E和TERT启动子突变在PTC中协同作用的最新进展。关键词:甲状腺肿瘤;突变;原癌基因蛋白B-raf;端粒酶;趋势

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Research progress of BRAFV600E and TERT promoter mutations coexistence in papillary thyroid cancer

Papillary thyroid cancer (PTC) is the most common pathological type of thyroid cancer, and its morbidity raises rapidly in the global world. V-raf murine sarcoma viral oncogene homolog B1 (BRAF)V600E mutation and telomerase reverse transcriptase (TERT) promoter mutations are the most common molecular markers of PTC. Nowadays, more and more studies find that the coexistence of BRAFV600E and TERT promoter mutations plays a synergistic role in the invasion and prognosis of PTC. This article reviews the recent advance in the synergism of BRAFV600E and TERT promoter mutations in PTC. Key words: Thyroid neoplasms; Mutation; Proto-oncogene proteins B-raf; Telomerase; Trends

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

自引率

0.00%

发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.