上肢骨折儿童和下肢骨折儿童25-OH维生素D水平的前瞻性病例对照研究

IF 1.1 4区医学 Q3 ORTHOPEDICS

Acta orthopaedica et traumatologica turcica Pub Date : 2022-03-01 DOI:10.5152/j.aott.2022.21018

Tuğrul Ergün, M. Cansever

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引用次数: 1

摘要

目的：本研究的目的是（1）比较上肢骨折儿童和下肢骨折儿童的25-OH维生素D水平；（2）确定与健康对照组相比，25-OH D缺乏的患病率是否增加。方法：这是一项为期12个月的前瞻性病例对照研究。该研究针对5-18岁的儿童，包括60名低能量创伤引起的非移位、嵌塞型上肢和下肢骨折的儿童。此外，60名健康儿童作为对照。在所有参与者中，评估了低骨密度的风险因素，并测量了血清25（OH）D水平。比较各组间的维生素D水平。结果：上肢和下肢骨折患者的维生素D缺乏（25-OH D<20）分别高14.8倍（OR=95%CI=5.61-39.8）和2.9倍（OR:95%CI=1.46-5.75）。上肢骨折组认为血清25-OH D水平不足（25-OH D = <20 ng/mL），占91.6%（55/60）。相比之下，它被认为是不足的（血清25-OH D水平 = 8.3%（5/60）的患者为20-30ng/mL。在下肢骨折组中，75.0%（45/60）的患者认为血清25（OH）D水平不足，25.0%（15/60）的病例认为血清25水平不足。在对照组中，10.0%（6/60）的受试者认为血清25-OH D水平不足，而61.6%（37/60）的受测者认为其不足。与健康对照组相比，25-OH D缺乏和功能不全在整个骨折组（上肢和下肢骨折组）中更常见。结论：本研究表明，维生素D缺乏与儿童骨折风险增加有关，上肢骨折的骨折风险高于下肢骨折。对于骨折儿童，应考虑常规维生素D评估。证据级别：三级，诊断研究

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Comparison of 25-OH vitamin D levels between children with upper and those with lower extremity fractures: A prospective case-control study

Objective: The aims of this study were (1) to compare 25-OH vitamin D levels between children with upper and those with lower extremity fractures and (2) to determine whether 25-OH D insufficiency prevalence is increased compared to healthy controls. Methods: This is a prospective case–control study for 12 months. The study was conducted with children aged 5-18 years, including 60 children with non-displaced, impaction type upper extremity and lower extremity fractures resulted from low-energy trauma. In addition, 60 healthy children were included as controls. In all participants, risk factors for low bone mineral density were assessed and serum 25(OH)D levels were measured. Vitamin D levels were compared among groups. Results: Vitamin D deficiency (25-OH D <20) was 14.8 times (OR= 95% CI= 5.61 - 39.8) and 2.9 times (OR= 95% CI= 1.46-5.75) higher in patients with upper and lower extremity fractures, respectively. In the upper extremity fracture group, serum 25-OH D level was considered deficient (25-OH D level = <20 ng/mL) in 91.6% (55/60). In comparison, it was considered as insufficient (serum 25-OH D level = 20-30 ng/mL in 8.3% (5/60) of the patients. In the lower extremity fracture group, serum 25(OH)D level was considered as deficient in 75.0% (45/60), while it was considered as insufficient in 25.0% (15/60) of the patients. In the control group, serum 25-OH D level was considered deficient in 10.0% (6/60), while it was considered insufficient in 61.6% (37/60) of subjects. The 25-OH D deficiency and insufficiency were more common in the whole fracture group (upper plus lower extremity fracture groups) when compared to healthy controls. Conclusion: This study has shown that hypovitaminosis D is associated with an increased risk for fracture in the pediatric population, and the fracture risk is higher in upper extremity fractures than in lower extremity fractures. In children with fractures, routine vitamin D evaluation should be considered. Level of Evidence: Level III, Diagnostic Study

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来源期刊

Acta orthopaedica et traumatologica turcica ORTHOPEDICS-

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Acta Orthopaedica et Traumatologica Turcica (AOTT) is an international, scientific, open access periodical published in accordance with independent, unbiased, and double-blinded peer-review principles. The journal is the official publication of the Turkish Association of Orthopaedics and Traumatology, and Turkish Society of Orthopaedics and Traumatology. It is published bimonthly in January, March, May, July, September, and November. The publication language of the journal is English. The aim of the journal is to publish original studies of the highest scientific and clinical value in orthopedics, traumatology, and related disciplines. The scope of the journal includes but not limited to diagnostic, treatment, and prevention methods related to orthopedics and traumatology. Acta Orthopaedica et Traumatologica Turcica publishes clinical and basic research articles, case reports, personal clinical and technical notes, systematic reviews and meta-analyses and letters to the Editor. Proceedings of scientific meetings are also considered for publication. The target audience of the journal includes healthcare professionals, physicians, and researchers who are interested or working in orthopedics and traumatology field, and related disciplines.