软通道微创治疗高血压脑出血的疗效观察及对高血压脑出血患者血清IL-18、VEGF、CRP、TNF-α的影响

中国基层医药 Pub Date : 2020-04-01 DOI:10.3760/CMA.J.ISSN.1008-6706.2020.07.019

Long Huang, Guoxing Mao

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The amount of intracranial hematoma in the observation group [(4.03±1.10)mL] was lower than that in the control group [(7.17±1.36)mL] (t=11.495, P<0.05). At 7 d after operation, the serum levels of IL-18[(123.74±10.27)ng/L], VEGF[(113.28±12.10)ng/L], CRP[(17.83±3.20)mg/L] and TNF-α[(0.65±0.12)ng/L] in the observation group were lower than those in the control group [(150.38±13.21)ng/L, (141.63±16.87)ng/L, (29.96±4.53)mg/L and (1.09±0.17)ng/L] (t=11.638, 9.101, 13.831, 5.569, all P<0.05). The NIHSS score of the observation group[(16.53±3.19)points] was lower than that of the control group[(23.43±4.65)points] at 3 months after operation (t=7.824, P<0.05). 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引用次数: 0

摘要

目的探讨软通道微创治疗高血压脑出血(HICH)的疗效及对血清白细胞介素-18 (IL-18)、血管内皮生长因子(VEGF)、c反应蛋白(CRP)、肿瘤坏死因子-α (TNF-α)的影响。方法选取2017年4月~ 2019年4月泰州市中医院收治的82例HICH患者，按随机数字表法随机分为观察组(41例)和对照组(41例)。对照组采用硬通道微创治疗，观察组采用软通道微创治疗。比较两组患者的治疗效果、术前及术后7 d的颅内血肿量、血清IL-18、VEGF、CRP、TNF-α水平、术前及术后3个月的神经功能缺损程度(NIHSS)评分及术后并发症。结果观察组总有效率(92.68%)高于对照组(70.73%)(χ2=6.609, P<0.05)。观察组颅内血肿量[(4.03±1.10)mL]低于对照组[(7.17±1.36)mL] (t=11.495, P<0.05)。术后7 d，观察组患者血清IL-18[(123.74±10.27)ng/L]、VEGF[(113.28±12.10)ng/L]、CRP[(17.83±3.20)mg/L]、TNF-α[(0.65±0.12)ng/L]水平均低于对照组[(150.38±13.21)ng/L、(141.63±16.87)ng/L、(29.96±4.53)mg/L、(1.09±0.17)ng/L] (t=11.638、9.101、13.831、5.569,P均<0.05)。观察组术后3个月NIHSS评分[(16.53±3.19)分]低于对照组[(23.43±4.65)分]，差异有统计学意义(t=7.824, P<0.05)。观察组并发症发生率(12.20%)低于对照组(34.15%)(χ2=5.549, P<0.05)。结论软通道微创治疗HICH疗效良好，可降低血清IL-18、VEGF、CRP、TNF-α水平的变化。关键词:颅内出血;高血压;外科手术，微创;软通道微创;硬通道微创;Interleukin-18;血管内皮生长因子;c反应蛋白;肿瘤坏死因子-α

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Observation of curative effect of soft channel minimally invasive treatment for hypertensive intracerebral hemorrhage and its influence on serum IL-18, VEGF, CRP and TNF-α in patients with hypertensive intracerebral hemorrhage

Objective To investigate the effect of soft channel minimally invasive treatment on hypertensive intracerebral hemorrhage (HICH) and its influence on serum interleukin-18 (IL-18), vascular endothelial growth factor (VEGF), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α). Methods From April 2017 to April 2019, 82 patients with HICH admitted to Taizhou Hospital of Traditional Chinese Medicine were randomly divided into observation group (41 cases) and control group (41 cases) according to random number table method.The control group was treated with hard channel minimally invasive treatment, while the observation group was treated with soft channel minimally invasive treatment.The therapeutic effect, intracranial hematoma volume, serum levels of IL-18, VEGF, CRP and TNF-α before and 7 days after operation, neurological deficit degree (NIHSS) scores before and 3 months after operation, and complications after operation were compared between the two groups. Results The total effective rate of the observation group (92.68%) was higher than that of the control group (70.73%) (χ2=6.609, P<0.05). The amount of intracranial hematoma in the observation group [(4.03±1.10)mL] was lower than that in the control group [(7.17±1.36)mL] (t=11.495, P<0.05). At 7 d after operation, the serum levels of IL-18[(123.74±10.27)ng/L], VEGF[(113.28±12.10)ng/L], CRP[(17.83±3.20)mg/L] and TNF-α[(0.65±0.12)ng/L] in the observation group were lower than those in the control group [(150.38±13.21)ng/L, (141.63±16.87)ng/L, (29.96±4.53)mg/L and (1.09±0.17)ng/L] (t=11.638, 9.101, 13.831, 5.569, all P<0.05). The NIHSS score of the observation group[(16.53±3.19)points] was lower than that of the control group[(23.43±4.65)points] at 3 months after operation (t=7.824, P<0.05). The incidence of complications in the observation group (12.20%) was lower than that in the control group (34.15%) (χ2=5.549, P<0.05). Conclusion Soft channel minimally invasive treatment for HICH has good effect and can reduce the changes of serum levels of IL-18, VEGF, CRP and TNF-α. Key words: Intracranial hemorrhage, hypertensive; Surgical procedures, minimally invasive; Soft channel minimally invasive; Hard channel minimally invasive; Interleukin-18; Vascular endothelial growth factor; C-reactive protein; Tumor necrosis factor-α

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来源期刊

中国基层医药

CiteScore

0.10

自引率

0.00%

发文量

32251

期刊介绍： Since its inception, the journal "Chinese Primary Medicine" has adhered to the development strategy of "based in China, serving the grassroots, and facing the world" as its publishing concept, reporting a large amount of the latest medical information at home and abroad, prospering the academic field of primary medicine, and is praised by readers as a medical encyclopedia that updates knowledge. It is a core journal in China's medical and health field, and its influence index (CI) ranks Q2 in China's academic journals in 2022. It was included in the American Chemical Abstracts in 2008, the World Health Organization Western Pacific Regional Medical Index (WPRIM) in 2009, and the Japan Science and Technology Agency Database (JST) and Scopus Database in 2018, and was included in the Wanfang Data-China Digital Journal Group and the China Academic Journal Comprehensive Evaluation Database.