放射基因组学的方法、挑战和未来发展方向

Novel approaches in cancer study Pub Date : 2020-04-29 DOI:10.31031/nacs.2020.04.000592

B. Qu

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摘要

组织对辐射的反应是一个复杂的病理生理过程，是一种遗传的多基因性状。放射基因组学研究的目的是发现将肿瘤或非肿瘤组织的放射敏感性作为放射增敏剂和/或放射保护剂目标的相关遗传变异，并确定用于预后或风险预测的特定遗传标记。放射基因组学研究的方法包括候选基因方法、全基因组关联研究、下一代研究等

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Methods, Challenges and Future Directions of Radiogenomics

Tissue response to the radiation is a complex pathophysiological process and is an inherited polygenic trait. Aim of the Radiogenomics studies is to discover related genetic variants that confer tumor or non-tumor tissue radio sensitivity as the target of radio-sensitizing and/or radio-protective agents and to identify specific genetic markers for prognosis or risk prediction. The methods for radiogenomics studies include candidate gene approaches, genome-wide association studies, Next-Generation

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Novel approaches in cancer study

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