P. Opute, I. Oboh, JE Asouzu, N. Pilani, E. Mbajiorgu
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Effects of atrazine on the endocrinology and histoarchitecture of the testes in African Catfish, Clarias gariepinus (Burchell, 1822)
Aquatic ecosystems often receive a wide spectrum of pollutants introduced directly or indirectly. The herbicide atrazine, an endocrine disrupting chemical (EDC), frequently contaminates potable water supplies and aquatic ecosystems. Studies suggest atrazine induced alterations in the neuroendocrine system along the hypothalamus-pituitary-gonadal (HPG) axis. This study investigated the effects of atrazine (0, 2.5, 25, 250 and 500 μg l−1 for 28 days of exposure) on testosterone (TST) and prolactin (PRL) levels, testes histology and seminiferous tubular morphometry of Clarias gariepinus juveniles. TST and PRL significantly decreased in all the 28 days atrazine exposed groups. Histologically, the testes showed vacuolated and sloughing of basal germinal epithelium in the treated groups. A high correlation between testicular biopsy score counts and results of seminiferous tubular morphometry was also observed. Findings from this study confirm that atrazine is an EDC in fish that alters reproductive dysfunction by targeting the HPG axis, as evidenced by its effects on the investigated reproductive hormones. Furthermore, atrazine disrupted the histoarchitectural components of the testes, which may interfere with spermatogenesis and therefore impair the reproductive functions of the fish.
期刊介绍:
The African Journal of Aquatic Science is an international journal devoted to the study of the aquatic sciences, covering all African inland and estuarine waters. The Journal publishes peer-reviewed original scientific papers and short articles in all the aquatic science fields including limnology, hydrobiology, ecology, conservation, biomonitoring, management, water quality, ecotoxicology, biological interactions, physical properties and human impacts on African aquatic systems.