应激颗粒生物学特性及其与肿瘤关系的研究进展

Q4 Medicine

肿瘤研究与临床 Pub Date : 2019-11-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2019.11.016

Xianying Li, Dalong Yin, Lianxin Liu

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引用次数: 0

摘要

真核细胞在应激条件下抑制信使核糖核酸的翻译并形成颗粒应激颗粒（应激颗粒）。目前，应激颗粒已被证明与包括肿瘤在内的多种疾病的发生和发展有关。肿瘤细胞中缺氧和高活性氧等微环境促进应激颗粒的产生，而应激颗粒相关蛋白G3BP1、RACK1、YB-1和哺乳动物雷帕霉素靶点（mTOR）可促进肿瘤的发生和转移，但其机制尚不清楚。此外，研究将应激颗粒的形成与化疗期间肿瘤细胞的存活联系起来，并认为应激颗粒在不同抗肿瘤药物治疗肿瘤中发挥作用。本文就应激颗粒的生物学特性及其与肿瘤的关系作一综述。关键词：肿瘤；应力颗粒；抗肿瘤药物

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Progress of biological characteristics of stress granules and their relationship with tumors

Eukaryotes inhibit the translation of mRNA under stress conditions and form particles-stress granules (stress granules). At present, stress granules have been proved to be related to the occurrence and development of a variety of diseases, including tumors. The production of stress granules is promoted by microenvironment such as hypoxia and hyperactive oxygen in tumor cells, while stress granules-related proteins such as G3BP1, RACK1, YB-1 and mammalian target of rapamycin (mTOR) can promote the occurrence and metastasis of tumors, but the mechanism is not yet clear. In addition, studies have linked the formation of stress granules to the survival of tumor cells during chemotherapy, and believe that stress granules play a role in the treatment of tumors by different anti-tumor drugs. This review introduces the biological characteristics of stress granules and their relationship with tumors. Key words: Neoplasms; Stress granules; Antineoplastic drugs

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.