{"title":"一些炎性细胞因子水平作为糖尿病标志物的评估","authors":"Abo-Zaid Mabrouk A, Mohammed Soha S, I. Ahmed H.","doi":"10.23937/2378-3672/1410065","DOIUrl":null,"url":null,"abstract":"From the different causes of death diabetes has an advanced rank in the first 10. So the aim of this study was to relate between some pro-inflammatory cytokines (TNF-α, IL-6, and TGF-β1) and infection with diabetes as biomarkers for infection. Forty male Wister albino Streptozotocin (STZ) induced diabetic rats were used as a model for estimation of the related cytokines. The animals were divided in two groups, the first group was given a placebo, whereas the second was given Streptozotocin at a single dose of 70 mg/kg body weight to induce diabetes mellitus. Each rat's blood glucose level was measured 72 hours later. Diabetes was successfully induced in rats with blood glucose levels greater than 300 mg/dl. After 7 days, all groups were sacrificed and immunological responses, tumor necrosis factor-alpha (TNF-α), interleukin (IL-6), and transforming growth factor (TGF-β1) were measured. Glucose levels were shown to be significantly higher in the group that was given Streptozotocin at a single dose of 70 mg/kg body weight, with a percent change of 217.5% when compared to the control group. While in the diabetic group, there was also a large increase in IL-6, TNF-α and TGF-β1 levels, with a percent change of 82.24%, 77.7% and 74.5% respectively. From these results we can recommend these cytokines as a biomarkers for diabetes mellitus disease.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Evaluation of Some Inflammatory Cytokines Levels as A Marker for Diabetes\",\"authors\":\"Abo-Zaid Mabrouk A, Mohammed Soha S, I. Ahmed H.\",\"doi\":\"10.23937/2378-3672/1410065\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"From the different causes of death diabetes has an advanced rank in the first 10. So the aim of this study was to relate between some pro-inflammatory cytokines (TNF-α, IL-6, and TGF-β1) and infection with diabetes as biomarkers for infection. Forty male Wister albino Streptozotocin (STZ) induced diabetic rats were used as a model for estimation of the related cytokines. The animals were divided in two groups, the first group was given a placebo, whereas the second was given Streptozotocin at a single dose of 70 mg/kg body weight to induce diabetes mellitus. Each rat's blood glucose level was measured 72 hours later. Diabetes was successfully induced in rats with blood glucose levels greater than 300 mg/dl. After 7 days, all groups were sacrificed and immunological responses, tumor necrosis factor-alpha (TNF-α), interleukin (IL-6), and transforming growth factor (TGF-β1) were measured. Glucose levels were shown to be significantly higher in the group that was given Streptozotocin at a single dose of 70 mg/kg body weight, with a percent change of 217.5% when compared to the control group. While in the diabetic group, there was also a large increase in IL-6, TNF-α and TGF-β1 levels, with a percent change of 82.24%, 77.7% and 74.5% respectively. From these results we can recommend these cytokines as a biomarkers for diabetes mellitus disease.\",\"PeriodicalId\":92912,\"journal\":{\"name\":\"International journal of immunology and immunotherapy\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of immunology and immunotherapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23937/2378-3672/1410065\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of immunology and immunotherapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23937/2378-3672/1410065","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evaluation of Some Inflammatory Cytokines Levels as A Marker for Diabetes
From the different causes of death diabetes has an advanced rank in the first 10. So the aim of this study was to relate between some pro-inflammatory cytokines (TNF-α, IL-6, and TGF-β1) and infection with diabetes as biomarkers for infection. Forty male Wister albino Streptozotocin (STZ) induced diabetic rats were used as a model for estimation of the related cytokines. The animals were divided in two groups, the first group was given a placebo, whereas the second was given Streptozotocin at a single dose of 70 mg/kg body weight to induce diabetes mellitus. Each rat's blood glucose level was measured 72 hours later. Diabetes was successfully induced in rats with blood glucose levels greater than 300 mg/dl. After 7 days, all groups were sacrificed and immunological responses, tumor necrosis factor-alpha (TNF-α), interleukin (IL-6), and transforming growth factor (TGF-β1) were measured. Glucose levels were shown to be significantly higher in the group that was given Streptozotocin at a single dose of 70 mg/kg body weight, with a percent change of 217.5% when compared to the control group. While in the diabetic group, there was also a large increase in IL-6, TNF-α and TGF-β1 levels, with a percent change of 82.24%, 77.7% and 74.5% respectively. From these results we can recommend these cytokines as a biomarkers for diabetes mellitus disease.