Postprandial Glycaemic Effect of a Peptide Fraction of Salvia Hispanica in Patients with Insulin Resistance

Abstract Diabetes is a prevalent metabolic disorder among almost every single population on the planet. Diet has a fundamental impact on both treatment and control. The consumption of several plant seeds has been associated with improvement in glucose tolerance and absorption. A randomized controlled trial was conducted to evaluate the glycaemic effects of a hydrolyzed peptide fraction of Salvia hispanica seed through postprandial quantification on blood glucose, plasma insulin, and Matsuda-DeFronzo index in patients with insulin resistance or incipient type 2 diabetes. Both Chia and control proteins were mixed with a portion of liquid food and provided to nine participants. A mixed-food tolerance curve was performed. A reduction in glucose concentrations was observed after 30 minutes in subjects consuming Chia seeds' peptides. However, no significant effect on plasmatic insulin was found. The consumption of peptide fractions of Chia seeds could decrease the acute absorption of carbohydrates and attenuate acute postprandial hyperglycemia in patients with T2D. However, these apparent benefits do not appear to modulate insulin sensitivity.