Expression of HER-2 in colorectal cancer and its relationship with clinicopathological features and prognosis

Objective To investigate the correlation between the expression of (epidermal growth factor receptor-2, HER-2) and clinicopathological features and survival of colorectal cancer. Methods From Jan 2005 to Dec 2015, all colorectal cancer cases were enrolled that the expression levels of HER-2 were detected in Guangdong Provincial People′s Hospital. Clinicopathological features of the tumors and survival of the patients were analyzed . Results A total of 1 463 cases were collected in 10 years, including 711 cases (48.6%) of HER-2 (-), 470 cases (32.1%) of HER-2 (+ ), 249 cases (17%) of HER-2 (+ + ), and 33 cases (2.3%) of HER-2 (+ + + ). Correlation analysis shows that the expression levels of HER-2 were significantly correlated with tumor differentiation and the depth of tumor invasion(T stage), but not correlated with gender, age, tumor location, N stage, M stage, TNM stage and overall survival, and disease-free survival. Conclusion The expression of HER-2 may be related to tumor differentiation and growth infiltration, but it cannot be used as a predictor of prognosis in patients with colorectal cancer. Key words: Colorectal neoplasms; Receptor, epidermal growth factor; Pathology, clinical; Prognosis