把片剂分开能得到准确的剂量吗?系统回顾和荟萃分析

IF 1 Q4 PHARMACOLOGY & PHARMACY
Kanika Chaudhri BMedSci (Hons), MD, Madeleine Kearney BMedSci, Gian Luca Di Tanna PhD, Sonali R. Gnanenthiran MBBS, PhD, Richard O. Day MBBS, PhD, Anthony Rodgers MBBS, PhD, Emily R. Atkins PhD
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引用次数: 0

摘要

片剂分裂是一种广泛流行的做法,由于需要将剂量改为两个或更多部分,并在个别患者中优化药物。如果药片分配不均,可能会出现问题。目的对片剂分裂对剂量准确性影响的文献进行综述。方法检索MEDLINE、EMBASE、CINAHL和Cochrane,纳入2020年1月前发表的关于片剂拆分对剂量准确性影响的研究。对任何药物的研究,只要片剂是分开的,都有可能符合条件。两名独立的审稿人进行了筛选并提取了数据。进行meta分析,评估片剂分裂对剂量准确性的影响。(研究注册:PROSPERO CRD42018106252)。结果在纳入的25项研究中,16项研究考察了片剂拆分对片剂重量的影响,1项研究考察了片剂浓度的影响,8项研究同时考察了片剂拆分对片剂质量和浓度的影响。meta分析发现,片剂间差异较小(重量差异为0.87%,95%可信区间为0.63% ~ 1.11%;药物含量差异为0.24%,95%可信区间为0.06% ~ 0.43%)。各试验结果在体重方面有一些不一致,但在药物含量变化方面没有不一致(分别为I2 50%和I2 1%)。分离方法和片剂特性是预测准确度的指标。结论虽然片剂分裂会影响剂量准确性,但本分析表明,无论方法和片剂特性如何,重量和药物含量变化都很小。需要进一步的研究,例如检查药物血浆浓度及其对患者健康结果(例如血压和胆固醇水平)的影响,以便更好地了解片剂分裂对剂量准确性的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Does splitting a tablet obtain an accurate dose? A systematic review and meta- analysis

Does splitting a tablet obtain an accurate dose? A systematic review and meta- analysis

Background

Tablet splitting is a widely prevalent practice resulting from the need to alter doses into two or more parts and optimise medicine in individual patients. If a tablet is split unequally problems may arise.

Aim

The aim of the study was to summarise the literature measuring the effect of tablet splitting on dose accuracy.

Method

MEDLINE, EMBASE, CINAHL and Cochrane were searched and studies published prior to January 2020 investigating the effect of splitting tablets on dose accuracy were included. Studies investigating any drug, where the tablet was split, were potentially eligible. Two independent reviewers conducted the screening and extracted the data. Meta-analyses assessing the effect of tablet splitting on dose accuracy were performed. (Study registration: PROSPERO CRD42018106252).

Results

Of 25 included studies, 16 examined the effect of tablet splitting on weight of the tablet, one on drug concentration and eight examined both. Meta-analysis found small variation between split tablets (0.87% weight variation, 95% confidence interval 0.63%–1.11% and 0.24% drug content variation, 95% confidence interval 0.06%–0.43%). There was some inconsistency across trial results for weight but not for drug content variation (I2 50% and I2 1%, respectively). Splitting method and tablet characteristics were predictors of accuracy.

Conclusion

Although tablet splitting may influence dose accuracy, this analysis suggests that the weight and drug content variation is minimal, regardless of method and tablet characteristics. Additional studies, such as those examining drug plasma concentrations and effect on patient health outcomes for example blood pressure and cholesterol levels, are needed to better understand the role of tablet splitting on dose accuracy.

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来源期刊
Journal of Pharmacy Practice and Research
Journal of Pharmacy Practice and Research Health Professions-Pharmacy
CiteScore
1.60
自引率
9.50%
发文量
68
期刊介绍: The purpose of this document is to describe the structure, function and operations of the Journal of Pharmacy Practice and Research, the official journal of the Society of Hospital Pharmacists of Australia (SHPA). It is owned, published by and copyrighted to SHPA. However, the Journal is to some extent unique within SHPA in that it ‘…has complete editorial freedom in terms of content and is not under the direction of the Society or its Council in such matters…’. This statement, originally based on a Role Statement for the Editor-in-Chief 1993, is also based on the definition of ‘editorial independence’ from the World Association of Medical Editors and adopted by the International Committee of Medical Journal Editors.
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