COVID-19病因学研究进展

Q4 Immunology and Microbiology

中华微生物学和免疫学杂志 Pub Date : 2020-04-15 DOI:10.3760/CMA.J.CN112309-20200312-00115

Kai Chen, Suwen Jiang, A. Hu

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引用次数: 1

摘要

2019年12月，严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）导致新冠肺炎在武汉爆发。它是一种包膜阳性链RNA病毒，属于Betacoronavirus属Sarbecovirus亚属。它在基因组结构上与Sarbecovirus亚属的其他病毒相似，并与蝙蝠冠状病毒（RaTG13）密切相关，表明其天然宿主很可能是蝙蝠，但中间宿主仍有争议。严重急性呼吸系统综合征冠状病毒2型以血管紧张素转换酶2（ACE2）为受体感染宿主细胞。目前，严重急性呼吸系统综合征冠状病毒2型已经发生了一些突变。本文综述了新冠肺炎病原学的研究现状和进展。关键词：新冠肺炎；严重急性呼吸系统综合征冠状病毒2型；病原学

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Advances in the etiology of COVID-19

In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the outbreak of COVID-19 in Wuhan. It is a kind of enveloped positive-strand RNA viruses, belonging to the subgenus Sarbecovirus of the genus Betacoronavirus. It is similar to other viruses of the subgenus Sarbecovirus in genomic structure and closely related to the bat coronavirus (RaTG13), indicating that its natural host is likely to be bat, but the intermediate host is still controversial. SARS-CoV-2 infects host cells with angiotensin-converting enzyme 2 (ACE2) as a receptor. At present, SARS-CoV-2 has undergone some mutations. This article reviewed the current research situation and progress in the etiology of COVID-19. Key words: COVID-19; Severe acute respiratory syndrome coronavirus 2; Etiology

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来源期刊

中华微生物学和免疫学杂志 Immunology and Microbiology-Virology

CiteScore

0.50

自引率

0.00%

发文量

6906

期刊介绍： Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.