金属暴露与乳腺恶性肿瘤:旁遮普省马尔瓦地区的病例对照研究

IF 1.3 Q4 ENVIRONMENTAL SCIENCES
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引用次数: 0

摘要

背景:癌症是由不可控制的乳腺细胞发育引发的。这些金属可能在人体血清和组织中积聚,导致雌激素/恶性后果。因此,人们正在研究金属是否会增加患癌症等内分泌相关恶性肿瘤的风险。方法:本研究评估了旁遮普省马尔瓦地区120名接受癌症手术的妇女的Cd、as、Pb、Ni、Cr、Zn和Fe等金属水平。患有恶性乳腺病变的受试者(n=83)被分为癌症病例组,而患有良性乳腺病变的患者(n=37)被分离为对照组。从每个病例中,获得血液、乳腺肿瘤和周围脂肪组织样本,并使用电感耦合等离子体质谱法(ICP-MS)进行金属分析。结果:在恶性病例中,肿瘤中的金属含量在0.04至139.18µg/kg之间。而在脂肪组织和血液中,其范围分别为0.04至1164.0µg/kg和0.02至276.61µg/kg。在对照组中,肿瘤中的总量为0.05至332.72µg/kg,脂肪组织中为0.13至125.61µg/kg,血液中为0.01至121.76µg/kg。观察到Cd、Cr、Zn、Fe、Ni和Pb的水平具有统计学意义/极显著性,而未在任何组中检测到砷。结论:Cd、Cr、Zn、Fe、Ni、Pb等元素在癌症的发生发展中可能起重要作用。肿瘤组织的实质成分以更高的速率积累重金属。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metal exposure and breast malignancy: A case-control study of Malwa Region of Punjab
Background: Breast cancer is triggered by uncontrollable breast cell development. These metals may build up in human serum and tissues, causing estrogenic/malignant consequences. Therefore, metals are being studied to investigate whether they enhance the risk of endocrine-related malignancies like breast cancer. Methods: This study assessed the level of metals such as Cd, As, Pb, Ni, Cr, Zn, and Fe in 120 women undergoing breast cancer surgery in the Malwa region of Punjab. Subjects having malignant breast lesions (n=83) were grouped in the cancer case group whereas subjects with benign breast lesions (n=37) were separated as a control group. From each case, blood, breast tumor, surrounding adipose tissue samples were obtained, and metal analysis was carried out using inductively coupled plasma mass spectrometry (ICP-MS). Results: In malignant cases, the amount of metals ranges from 0.04 to 139.18 µg/kg in tumor. Whereas in adipose tissues and blood, it ranges from 0.04 to 1164.0 µg/kg and from 0.02 to 276.61 µg/kg, respectively. In control group, the total amount ranges from 0.05 to 332.72 µg/kg in the tumor, from 0.13 to 125.61 µg/kg in adipose tissues, and from 0.01 to 121.76 µg/kg in the blood. The level of Cd, Cr, Zn, Fe, Ni, and Pb were observed to be statistically significant/extremely significant whereas Arsenic was detected in no groups. Conclusion: The results indicate that Cd, Cr, Zn, Fe, Ni, and Pb may play a significant role in the development of breast cancer. The parenchymal component of tumor tissues accumulates heavy metals at a higher rate.
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来源期刊
CiteScore
2.40
自引率
37.50%
发文量
17
审稿时长
12 weeks
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