NUSAP1、MELK和L1CAM免疫组化表达在癌症中的预后和临床病理意义

IF 0.4 Q4 ONCOLOGY

Middle East Journal of Cancer Pub Date : 2020-10-10 DOI:10.30476/MEJC.2020.82884.1115

M. Elfeky, O. Harb, B. Shafaay, A. Obaya, Amr A. Awd, Mohamed M. Alkilany, L. Gertallah

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引用次数: 1

摘要

背景：癌症宫颈预后评估对于新的靶向治疗和改善预后是非常必要的。细胞核和纺锤体相关蛋白1（NUSAP1）是一种新的生物标志物，在纺锤体形成和有丝分裂过程中发挥作用。母体胚胎亮氨酸拉链激酶（MELK）参与细胞周期控制和致癌作用。L1细胞粘附分子（L1-CAM）在细胞迁移中起着重要作用。本研究旨在研究NUSAP1、MELK和L1CAM在癌症宫颈组织中的免疫组化表达，并检测它们的预后作用。方法：在这项前瞻性队列研究中，我们使用免疫组织化学方法评估了62例宫颈癌切片中NUSAP1、MELK和L1CAM的表达。结果：NUSAP1、MELK和L1CAM的表达与肿瘤分级高、FIGO晚期、生存率低、治疗成功后复发率高相关（p＜0.001）。

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Prognostic and Clinicopathological Implications of NUSAP1, MELK and L1CAM Immunohistochemical Expression in Cervical Cancer

Background: Evaluation of cancer cervix prognosis is highly needed for novel targeted therapy and improved outcomes. Nucleolar and spindle associated protein 1 (NUSAP1) is a novel biomarker that has roles in spindle formation and mitotic progression. Maternal embryonic leucine zipper kinase (MELK) is involved in cell cycle control and carcinogenesis. The L1 cell adhesion molecule (L1-CAM) plays an essential role in cell migration. This study aimed to investigate NUSAP1, MELK, and L1CAM immunohistochemical expression in cancer cervix tissues and detect their prognostic roles. Method: In this prospective cohort study, we evaluated NUSAP1, MELK, and L1CAM expressions of sections from 62 cervical carcinoma cases using immunohistochemistry. Results: NUSAP1, MELK, and L1CAM expression correlated with tumor high grade, advanced FIGO stage, poor survival rates, and higher recurrence rate after successful therapy (p <0.001). Conclusion: Expression of NUSAP1, MELK, and L1CAM in cancer cervix was associated with poor prognosis.

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来源期刊

Middle East Journal of Cancer ONCOLOGY-

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Middle East Journal of Cancer (MEJC) is an international peer-reviewed journal which aims to publish high-quality basic science and clinical research in the field of cancer. This journal will also reflect the current status of research as well as diagnostic and treatment practices in the field of cancer in the Middle East, where cancer is becoming a growing health problem. Lastly, MEJC would like to become a model for regional journals with an international outlook. Accordingly, manuscripts from authors anywhere in the world will be considered for publication. MEJC will be published on a quarterly basis.