基于营养状况的严重血友病A出血发作的差异

Wenny Simamora, Susi Susanah, A. Oehadian
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引用次数: 0

摘要

背景:血友病A是一种由凝血因子VIII缺乏引起的先天性出血性疾病,其特征是关节出血,尤其是负重关节出血。由于关节张力增加,超重可能会导致血友病出血。本研究旨在确定有和没有超重的严重血友病A患者出血事件的差异。方法:2019年3月至11月,采用横断面设计进行了一项比较观察性分析研究。受试者是在西爪哇印尼血友病协会注册的严重血友病A患者,患有严重血友病A至少两年,出生日期、身高、体重和出血强度数据完整。受试者被分为超重组(超重)和非超重组(非超重)。成年人的营养状况是根据特定年龄的百分位BMI来确定的。出血事件被确定为一年内出血的频率。使用Mann-Whitney统计检验来观察各组之间的差异。结果:在登记的226例严重血友病A患者中,只有155例被纳入。其中,121名患者没有超重,34名患者超重。非超重组和超重组的中位出血次数分别为24(1-48)和24(8-48)(p=0.761)。然而,需要为这些患者提供良好的营养教育,因为超重可能会增加关节出血。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Differences in Bleeding Episodes in Severe Hemophilia A Based on Nutritional Status
Background: Hemophilia A is a congenital bleeding disorder caused by the deficiency of coagulation factor VIII and is characterized by joint bleeding, especially in weight-bearing joints. An excess weight may cause bleeding in hemophilia due to increased joint tension. This study aimed to determine the differences in bleeding episodes between severe hemophilia A patients with and without excess weight. Method: A comparative observational analytic study was conducted in March-November 2019 using a cross-sectional design. Subjects were patients with severe hemophilia A registered in the Indonesian Hemophilia Society Association in West Java and had had severe hemophilia A for at least two years old with complete data on date of birth, height, weight, and bleeding intensity. Subjects were divided into groups with excess weight (excess weight) and without excess weight (non-excess weight). Nutritional status in adults was determined based on age-specific percentile BMI. Bleeding episodes were determined as frequency of bleeding in one year. The Mann-Whitney statistical test was used to observe the difference between groups. Result: Of 226 severe hemophilia A patients registered, only 155 patients were included. Of these, 121 patients did not have excess weight and 34 had excess weight. The median bleeding episodes of in the non-excess weight and excess weight groups were 24(1-48) and 24(8-48), respectively (p=0.761). Conclusion: There is no difference in bleeding episodes Between severe hemophilia A patients with excess weight and without excess weight. However, good nutrition education needs to be provided to these patients since excess weight may increase bleeding in joints.
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