生长抑素联合早期血液灌流对急性胰腺炎治疗过程中炎症、血液流变学和氧化参数的影响。

IF 0.1 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Hengyong Zhai, Bin Yang, Yiwei Fu, Dongli Zhang, Yujiang Li, Junxing Huang
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引用次数: 0

摘要

我们旨在评估生长抑素联合早期血液灌流对急性泛肌炎(AP)治疗期间炎症和应激反应的影响。2016年9月至2020年1月,共有159名接受治疗的AP患者被随机分为A-C三组(n=53)。除常规治疗外,A-C组分别给予生长抑素、早期血液灌流和生长抑素联合早期血液灌灌流。比较其炎症因子、应激反应、肠黏膜屏障、血液流变学指标、恢复时间、住院时间、临床疗效和不良反应。治疗10天后,三组血清白细胞介素-10(IL-10)、过氧化氢酶和谷胱甘肽过氧化物酶水平均较治疗前升高,其中C组升高幅度最大。IL-18、肿瘤坏死因子-α、可溶性细胞间粘附分子-1、降钙素原、高迁移率组蛋白B1、脂质过氧化氢、,晚期氧化蛋白产物、肾上腺素、皮质醇、D-乳酸、二胺氧化酶和内毒素在治疗10天后较治疗前下降,C组最低(P<0.05)。治疗10天后,血液流变学指标显著低于治疗前(P<0.05),C组尿淀粉酶、肠鸣气恢复时间短,腹痛缓解时间短,住院时间长,总有效率高(P<0.05)。AP治疗期间,生长抑素联合早期血液灌流有效缓解炎症和应激反应,保护肠黏膜屏障功能,改善血液流变学,从而促进患者的康复并有利于患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of somatostatin in combination with early hemoperfusion on inflammatory, hemorheological and oxidative parameters during the treatment of acute pancreatitis.
We aimed to evaluate the effects of somatostatin combined with early hemoperfusion on inflammatory and stress responses during acute pan-creatitis (AP) treatment.A total of 159 AP patients treated from September 2016 to January 2020 were randomly divided into three groups A-C (n=53). In addition to routine treatment, groups A-C were additionally given somatostatin, early hemoperfusion, and somatostatin combined with early hemoperfusion, re-spectively. Their inflammatory factors, stress response, intestinal mucosal bar-rier, hemorheological indices, recovery time, length of stay, clinical efficacy, and adverse reactions were compared. The levels of serum interleukin-10 (IL -10), catalase and glutathione peroxidase rose in the three groups after ten days of treatment, compared with values before treatment, being the highest rise in group C. The levels of IL -18, tumor necrosis factor-α, soluble intercellular adhe-sion molecule-1, procalcitonin, high mobility group protein B1, lipid hydrogen peroxide, advanced oxidation protein products, epinephrine, cortisol, D-lactic acid, diamine oxidase, and endotoxin decreased after ten days of treatment compared with those before treatment, which were lowest in group C (P<0.05). After ten days of treatment, the levels of hemorheological indices were signifi-cantly lower than those before treatment (P<0.05). Compared with groups A and B, group C had a shorter recovery time of urine amylase, bowel sound and passing gas, remission time of abdominal pain, length of stay, and a higher to-tal response rate (P<0.05).During AP treatment, somatostatin combined with early hemoperfusion effectively relieved inflammatory and stress responses, protected the intestinal mucosal barrier function and improved the hemorheol-ogy, thereby promoting the recovery and benefiting the prognosis of patients.
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来源期刊
Investigacion clinica
Investigacion clinica MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
0.20
自引率
50.00%
发文量
2
审稿时长
>12 weeks
期刊介绍: Estudios humanos, animales y de laboratorio relacionados con la investigación clínica y asuntos conexos.
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